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3MJA
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Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate, structure #2
Descriptor: Domain 3 of the cricket paralysis virus intergenic region IRES RNA, RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3'), SELENATE ION
Authors:Kieft, J.S, Golden, B.L, Costantino, D.A, Chase, E.
Deposit date:2010-04-12
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification and characterization of anion binding sites in RNA.
Rna, 16, 2010
2QUJ
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BU of 2quj by Molmil
Crystal structures of human tryptophanyl-tRNA synthetase in complex with TrpAMP
Descriptor: CHLORIDE ION, GLYCEROL, TRYPTOPHAN, ...
Authors:Shen, N, Ding, J.P.
Deposit date:2007-08-05
Release date:2008-04-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res., 36, 2008
2QUH
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Crystal structures of human tryptophanyl-tRNA synthetase in complex with Trp
Descriptor: TRYPTOPHAN, Tryptophanyl-tRNA synthetase
Authors:Shen, N, Ding, J.P.
Deposit date:2007-08-05
Release date:2008-04-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res., 36, 2008
2QUI
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BU of 2qui by Molmil
Crystal structures of human tryptophanyl-tRNA synthetase in complex with Tryptophanamide and ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, L-TRYPTOPHANAMIDE, MAGNESIUM ION, ...
Authors:Shen, N, Ding, J.P.
Deposit date:2007-08-05
Release date:2008-04-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res., 36, 2008
4EO4
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BU of 4eo4 by Molmil
Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Threonine--tRNA ligase, mitochondrial, ...
Authors:Peterson, K.M, Ling, J, Simonovic, I, Soll, D, Simonovic, M.
Deposit date:2012-04-13
Release date:2012-07-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:The mechanism of pre-transfer editing in yeast mitochondrial threonyl-tRNA synthetase.
J.Biol.Chem., 287, 2012
4PHC
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BU of 4phc by Molmil
Crystal Structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound
Descriptor: GLYCEROL, HISTIDINE, Histidine--tRNA ligase, ...
Authors:Koh, C.Y, Wetzel, A.B, de van der Schueren, W.J, Hol, W.G.J.
Deposit date:2014-05-06
Release date:2014-08-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.
Biochimie, 106, 2014
5IFU
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BU of 5ifu by Molmil
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Glyburide
Descriptor: 1,2-ETHANEDIOL, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, CHLORIDE ION, ...
Authors:Dranow, D.M, Hewitt, S.N, Abendroth, J, Structural Genomics Consortium (SGC)
Deposit date:2016-02-26
Release date:2016-11-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
ACS Infect Dis, 3, 2017
5FOM
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BU of 5fom by Molmil
Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with the adduct AMP-AN6426
Descriptor: 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION
Authors:Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
Deposit date:2015-11-24
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOG
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BU of 5fog by Molmil
Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of norvaline (Nv2AA)
Descriptor: 1,2-ETHANEDIOL, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, LEUCYL-TRNA SYNTHETASE, ...
Authors:Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
Deposit date:2015-11-20
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOL
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BU of 5fol by Molmil
Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of isoeucine (Ile2AA)
Descriptor: 2'-(L-ISOLEUCYL)AMINO-2'-DEOXYADENOSINE, LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION
Authors:Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
Deposit date:2015-11-24
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
4WI1
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BU of 4wi1 by Molmil
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with TCMDC-124506
Descriptor: 1,2-ETHANEDIOL, 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2014-09-25
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Acs Infect Dis., 2016
7OSZ
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BU of 7osz by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4d
Descriptor: 3-[(2-methylphenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT0
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BU of 7ot0 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4h
Descriptor: 3-[(2-chlorophenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OSY
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BU of 7osy by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline
Descriptor: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT1
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BU of 7ot1 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3c
Descriptor: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT3
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BU of 7ot3 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3b
Descriptor: Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
7OT2
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BU of 7ot2 by Molmil
Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4j
Descriptor: 3-[[2-(trifluoromethyl)phenyl]methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ...
Authors:Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D.
Deposit date:2021-06-09
Release date:2021-07-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
Int J Mol Sci, 22, 2021
5F5W
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BU of 5f5w by Molmil
Crystal structure of the alpha subunit of glycyl tRNA synthetase (GlyRS) from Aquifex aeolicus in complex with an analog of glycyl adenylate (Gly-SA)
Descriptor: 5'-O-(glycylsulfamoyl)adenosine, Glycine--tRNA ligase alpha subunit
Authors:Valencia-Sanchez, M.I, Torres-Larios, A.
Deposit date:2015-12-04
Release date:2016-05-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases.
J.Biol.Chem., 291, 2016
6HHZ
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BU of 6hhz by Molmil
Klebsiella pneumoniae Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)cytidine, CALCIUM ION, ...
Authors:Pang, L, De Graef, S, Weeks, S.D, Strelkov, S.V.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HHY
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BU of 6hhy by Molmil
Klebsiella pneumoniae Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, CALCIUM ION, ...
Authors:Pang, L, De Graef, S, Weeks, S.D, Strelkov, S.V.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
4YDQ
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BU of 4ydq by Molmil
Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum in complex with Halofuginone and AMPPNP
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Yogavel, M, Sharma, A.
Deposit date:2015-02-23
Release date:2015-05-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis
Structure, 23, 2015
1WYD
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BU of 1wyd by Molmil
Crystal Structure of Aspartyl-tRNA synthetase from Sulfolobus tokodaii
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, SULFATE ION, ...
Authors:Maeda, Y, Hossain, M.T, Ubukata, S, Suzuki, K, Sekiguchi, T, Takenaka, A.
Deposit date:2005-02-12
Release date:2006-07-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the nondiscriminating aspartyl-tRNA synthetase from the crenarchaeon Sulfolobus tokodaii strain 7 reveals the recognition mechanism for two different tRNA anticodons
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
6HDZ
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BU of 6hdz by Molmil
Pseudomonas aeruginosa Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-Sulfamoyl)uridine, SODIUM ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2018-08-20
Release date:2019-12-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HE3
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BU of 6he3 by Molmil
Pseudomonas aeruginosa Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)cytidine, SODIUM ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2018-08-20
Release date:2019-12-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HE1
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BU of 6he1 by Molmil
Pseudomonas aeruginosa Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, SODIUM ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2018-08-20
Release date:2019-12-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020

238582

數據於2025-07-09公開中

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