4YDQ

Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum in complex with Halofuginone and AMPPNP

Summary for 4YDQ

Entry DOI	10.2210/pdb4ydq/pdb
Related	4HVC 4TWA
Descriptor	Proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (5 entities in total)
Functional Keywords	prolyl-trna synthetase, complex, halofuginone, malaria, ligase
Biological source	Plasmodium falciparum
Cellular location	Cytoplasm : Q8I5R7
Total number of polymer chains	2
Total formula weight	117492.74
Authors	Jain, V.,Yogavel, M.,Sharma, A. (deposition date: 2015-02-23, release date: 2015-05-20, Last modification date: 2023-11-08)
Primary citation	Jain, V.,Yogavel, M.,Oshima, Y.,Kikuchi, H.,Touquet, B.,Hakimi, M.A.,Sharma, A. Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis Structure, 23:819-829, 2015 Cited by PubMed: 25817387 DOI: 10.1016/j.str.2015.02.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation