4YDQ
Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Plasmodium falciparum in complex with Halofuginone and AMPPNP
Summary for 4YDQ
Entry DOI | 10.2210/pdb4ydq/pdb |
Related | 4HVC 4TWA |
Descriptor | Proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (5 entities in total) |
Functional Keywords | prolyl-trna synthetase, complex, halofuginone, malaria, ligase |
Biological source | Plasmodium falciparum |
Cellular location | Cytoplasm : Q8I5R7 |
Total number of polymer chains | 2 |
Total formula weight | 117492.74 |
Authors | Jain, V.,Yogavel, M.,Sharma, A. (deposition date: 2015-02-23, release date: 2015-05-20, Last modification date: 2023-11-08) |
Primary citation | Jain, V.,Yogavel, M.,Oshima, Y.,Kikuchi, H.,Touquet, B.,Hakimi, M.A.,Sharma, A. Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis Structure, 23:819-829, 2015 Cited by PubMed: 25817387DOI: 10.1016/j.str.2015.02.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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