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5FOG

Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of norvaline (Nv2AA)

Summary for 5FOG
Entry DOI10.2210/pdb5fog/pdb
DescriptorLEUCYL-TRNA SYNTHETASE, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordslyase, cryptosporidium, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) give amp + diphosphate + l-leucyl-trna(leucine), post-transfer editing activity of leurs, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of the editing site of leurs
Biological sourceCRYPTOSPORIDIUM MURIS
Total number of polymer chains4
Total formula weight133681.13
Authors
Palencia, A.,Liu, R.J.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.D.,Alley, M.R.K.,Rosenthal, P.J.,Hakimi, M.A.,Cusack, S. (deposition date: 2015-11-20, release date: 2016-08-03, Last modification date: 2024-01-10)
Primary citationPalencia, A.,Liu, R.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.,Li, X.,Alley, M.R.K.,Freund, Y.R.,Rosenthal, P.J.,Hakimi, M.,Cusack, S.
Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60:5817-, 2016
Cited by
PubMed: 27431220
DOI: 10.1128/AAC.00873-16
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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