5FOG

Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of norvaline (Nv2AA)

Summary for 5FOG

DescriptorLEUCYL-TRNA SYNTHETASE, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordslyase, cryptosporidium, leucine-trna ligase (leurs) activity, atp + l-leucine + trna(leucine) give amp + diphosphate + l-leucyl-trna(leucine), post-transfer editing activity of leurs, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of the editing site of leurs
Biological sourceCRYPTOSPORIDIUM MURIS
Total number of polymer chains4
Total molecular weight133681.13
Authors
Palencia, A.,Liu, R.J.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.D.,Alley, M.R.K.,Rosenthal, P.J.,Hakimi, M.A.,Cusack, S. (deposition date: 2015-11-20, release date: 2016-08-03, Last modification date: 2016-10-05)
Primary citation
Palencia, A.,Liu, R.,Lukarska, M.,Gut, J.,Bougdour, A.,Touquet, B.,Wang, E.,Li, X.,Alley, M.R.K.,Freund, Y.R.,Rosenthal, P.J.,Hakimi, M.,Cusack, S.
Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60:5817-, 2016
PubMed: 27431220 (PDB entries with the same primary citation)
DOI: 10.1128/AAC.00873-16
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23610.1%1.0%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution