5FOG
Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of norvaline (Nv2AA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| A | 0004823 | molecular_function | leucine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| B | 0004823 | molecular_function | leucine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| C | 0004823 | molecular_function | leucine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| D | 0004823 | molecular_function | leucine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006429 | biological_process | leucyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE VRT A 1542 |
| Chain | Residue |
| A | ALA286 |
| A | ASP433 |
| A | LYS496 |
| A | HOH2006 |
| A | HOH2007 |
| A | HOH2049 |
| A | THR287 |
| A | LEU288 |
| A | THR292 |
| A | SER415 |
| A | LYS418 |
| A | GLY421 |
| A | VAL423 |
| A | THR424 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1543 |
| Chain | Residue |
| A | TYR434 |
| A | ARG438 |
| A | LYS441 |
| A | PRO460 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE VRT B 1542 |
| Chain | Residue |
| B | TYR258 |
| B | ALA286 |
| B | THR287 |
| B | LEU288 |
| B | ARG289 |
| B | THR292 |
| B | SER415 |
| B | LYS418 |
| B | GLY421 |
| B | VAL423 |
| B | THR424 |
| B | SER430 |
| B | ASP433 |
| B | LYS496 |
| B | HOH2009 |
| B | HOH2010 |
| B | HOH2052 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1543 |
| Chain | Residue |
| A | PHE412 |
| A | LYS449 |
| B | TYR505 |
| B | LYS518 |
| B | CYS520 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE VRT C 1542 |
| Chain | Residue |
| C | ALA286 |
| C | THR287 |
| C | LEU288 |
| C | THR292 |
| C | SER415 |
| C | LYS418 |
| C | GLY421 |
| C | VAL423 |
| C | THR424 |
| C | ASP433 |
| C | LYS496 |
| C | HOH2014 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 1543 |
| Chain | Residue |
| B | PHE407 |
| B | GLU455 |
| C | GLU462 |
| C | ARG511 |
| C | EDO1544 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 1544 |
| Chain | Residue |
| B | GLU455 |
| B | LEU458 |
| C | TYR294 |
| C | PRO402 |
| C | ARG511 |
| C | EDO1543 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K C 1545 |
| Chain | Residue |
| C | ALA398 |
| C | THR401 |
| C | TYR403 |
| C | HOH2046 |
| C | HOH2049 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE VRT D 1542 |
| Chain | Residue |
| D | ALA286 |
| D | THR287 |
| D | LEU288 |
| D | THR292 |
| D | SER415 |
| D | LYS418 |
| D | GLY421 |
| D | VAL423 |
| D | THR424 |
| D | ASP433 |
| D | LYS496 |
| D | HOH2007 |
| D | HOH2008 |
| D | HOH2052 |
| D | HOH2108 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 1543 |
| Chain | Residue |
| D | ALA398 |
| D | THR401 |
| D | TYR403 |
| D | HOH2034 |
| D | HOH2035 |
| D | HOH2038 |
