2QUI

Crystal structures of human tryptophanyl-tRNA synthetase in complex with Tryptophanamide and ATP

Summary for 2QUI

• Entry DOI: 10.2210/pdb2qui/pdb
• Related: 1O5T 2AKE
• Descriptor: Tryptophanyl-tRNA synthetase, MAGNESIUM ION, L-TRYPTOPHANAMIDE, ... (5 entities in total)
• Functional Keywords: aminoacyl-trna synthetase, rossmann fold, induced-fit mechnism, atp-binding, cytoplasm, ligase, nucleotide-binding, protein biosynthesis
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P23381
• Total number of polymer chains: 2
• Total formula weight: 109058.19

Authors

Shen, N.,Ding, J.P. (deposition date: 2007-08-05, release date: 2008-04-29, Last modification date: 2023-11-15)

• Primary citation: Shen, N.,Zhou, M.,Yang, B.,Yu, Y.,Dong, X.,Ding, J.; Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states; Nucleic Acids Res., 36:1288-1299, 2008; PubMed: 18180246; DOI: 10.1093/nar/gkm1153

Experimental method

X-RAY DIFFRACTION (2.4 Å)