2QUI
Crystal structures of human tryptophanyl-tRNA synthetase in complex with Tryptophanamide and ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001525 | biological_process | angiogenesis |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045765 | biological_process | regulation of angiogenesis |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001525 | biological_process | angiogenesis |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0045765 | biological_process | regulation of angiogenesis |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 500 |
| Chain | Residue |
| A | SER165 |
| A | LYS200 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LTN A 501 |
| Chain | Residue |
| A | LYS200 |
| A | GLN284 |
| A | CYS309 |
| A | GLN313 |
| A | PHE317 |
| A | TYR159 |
| A | THR160 |
| A | GLY161 |
| A | GLY163 |
| A | GLN194 |
| A | THR196 |
| A | GLU199 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LTN B 478 |
| Chain | Residue |
| B | TYR159 |
| B | THR160 |
| B | GLY161 |
| B | GLY163 |
| B | GLN194 |
| B | THR196 |
| B | GLU199 |
| B | LYS200 |
| B | GLN284 |
| B | CYS309 |
| B | GLN313 |
| B | PHE317 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ATP A 502 |
| Chain | Residue |
| A | ARG162 |
| A | GLY163 |
| A | SER165 |
| A | ALA168 |
| A | HIS170 |
| A | GLY172 |
| A | HIS173 |
| A | ASP312 |
| A | GLN313 |
| A | PHE339 |
| A | PHE340 |
| A | LYS349 |
| A | MET350 |
| A | SER351 |
| A | ALA352 |
| A | SER353 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Motif: {"description":"'HIGH' region","evidences":[{"source":"PubMed","id":"1373391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"'KMSKS' region","evidences":[{"source":"PubMed","id":"1373391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P32921","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| A | ALA352 | |
| A | LYS349 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| B | ALA352 | |
| B | LYS349 |
