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1LUN	NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2024-10-16 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUM	NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2024-10-16 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUK	NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2024-10-30 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures Descriptor: Tyrosine-protein kinase ITK/TSK Authors: Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. Deposit date: 2002-05-22 Release date: 2002-11-27 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LKL	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE) Descriptor: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LKK	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE) Descriptor: ACETYL GROUP, HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE Authors: Tong, L. Deposit date: 1995-11-10 Release date: 1996-03-08 Last modified: 2024-08-07 Method: X-RAY DIFFRACTION (1 Å) Cite: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1LCK	SH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA Descriptor: P56==LCK== TYROSINE KINASE, TAIL PHOSPHOPEPTIDE TEGQ(PHOSPHO)YQPQPA Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature, 368, 1994
1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL Descriptor: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1KSW	Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP Descriptor: N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. Deposit date: 2002-01-14 Release date: 2002-02-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9, 2002
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide Descriptor: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase Authors: Lubman, O.Y, Waksman, G. Deposit date: 2001-11-07 Release date: 2002-04-17 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1KA7	SAP/SH2D1A bound to peptide n-Y-c Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY Descriptor: SH2 DOMAIN PROTEIN 1A, peptide n-pY Authors: Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. Deposit date: 2001-10-31 Release date: 2001-11-07 Last modified: 2021-10-27 Method: SOLUTION NMR Cite: A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1K9A	Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution Descriptor: Carboxyl-terminal Src kinase Authors: Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T. Deposit date: 2001-10-28 Release date: 2002-03-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of the carboxyl-terminal Src kinase, Csk. J.Biol.Chem., 277, 2002
1JYU	Xray Structure of Grb2 SH2 Domain Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JYR	Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK Descriptor: Csk Homologous Kinase Authors: Murthy, T.V.S, Webster, G.D. Deposit date: 2001-09-04 Release date: 2001-09-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1JU5	Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy Descriptor: Abl, Crk Authors: Donaldson, L.W, Pawson, T, Kay, L.E, Forman-Kay, J.D. Deposit date: 2001-08-23 Release date: 2002-11-06 Last modified: 2024-10-16 Method: SOLUTION NMR Cite: Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide Proc.Natl.Acad.Sci.USA, 99, 2002
1IS0	Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor Descriptor: AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC Authors: Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. Deposit date: 2001-11-02 Release date: 2002-02-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J.Am.Chem.Soc., 124, 2002
1IJR	Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic Descriptor: (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK Authors: Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. Deposit date: 2001-04-27 Release date: 2002-05-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11, 2001
1I3Z	MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE Descriptor: EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE Authors: Lu, J, Poy, F, Morra, M, Terhorst, C, Eck, M.J. Deposit date: 2001-02-19 Release date: 2003-04-08 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. Eur.J.Biochem., 20, 2001
1HCT	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC Authors: Gampe Junior, R.T, Xu, R.X. Deposit date: 1994-09-02 Release date: 1995-09-15 Last modified: 2024-10-30 Method: SOLUTION NMR Cite: Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
1HCS	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC Authors: Gampe Junior, R.T, Xu, R.X. Deposit date: 1994-09-02 Release date: 1995-09-15 Last modified: 2024-10-30 Method: SOLUTION NMR Cite: Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
1H9O	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A Descriptor: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE Authors: Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A. Deposit date: 2001-03-14 Release date: 2001-03-19 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.79 Å) Cite: NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex Acta Crystallogr.,Sect.D, 57, 2001
1GRI	GRB2 Descriptor: GROWTH FACTOR BOUND PROTEIN 2 Authors: Maignan, S, Arnoux, B, Ducruix, A. Deposit date: 1995-02-28 Release date: 1996-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal structure of the mammalian Grb2 adaptor. Science, 268, 1995

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