5YT3
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![BU of 5yt3 by Molmil](/molmil-images/mine/5yt3) | Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant | Descriptor: | MAGNESIUM ION, Mitogen-activated protein kinase kinase 1, isoform CRA_d, ... | Authors: | Nakae, S, Doko, K, Tada, T, Shirai, T. | Deposit date: | 2017-11-16 | Release date: | 2018-11-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant To Be Published
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7KMR
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5YBU
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![BU of 5ybu by Molmil](/molmil-images/mine/5ybu) | Structure of the KANK1 ankyrin domain in complex with KIF21A peptide | Descriptor: | KN motif and ankyrin repeat domain-containing protein 1, Kinesin-like protein KIF21A | Authors: | Guo, Q, Liao, S, Min, J, Xu, C, Structural Genomics Consortium (SGC) | Deposit date: | 2017-09-05 | Release date: | 2017-12-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J. Biol. Chem., 293, 2018
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7CFW
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![BU of 7cfw by Molmil](/molmil-images/mine/7cfw) | Crystal structure of the receiver domain of sensor histidine kinase PA1611 (PA1611REC) from Pseudomonas aeruginosa PAO1 with calcium ion coordinated in the active site cleft | Descriptor: | CALCIUM ION, Histidine kinase | Authors: | Chen, S.K, Guan, H.H, Wu, P.H, Lin, L.T, Wu, M.C, Chang, H.Y, Chen, N.C, Lin, C.C, Chuankhayan, P, Huang, Y.C, Lin, P.J, Chen, C.J. | Deposit date: | 2020-06-29 | Release date: | 2020-11-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structural insights into the histidine-containing phospho-transfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa Iucrj, 7, 2020
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5YCE
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![BU of 5yce by Molmil](/molmil-images/mine/5yce) | Sperm whale myoglobin swMb | Descriptor: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Isogai, Y, Imamura, H, Nakae, S, Sumi, T, Takahashi, K, Nakagawa, T, Tsuneshige, A, Shirai, T. | Deposit date: | 2017-09-07 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (0.77 Å) | Cite: | Tracing whale myoglobin evolution by resurrecting ancient proteins. Sci Rep, 8, 2018
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5UHU
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8EML
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![BU of 8eml by Molmil](/molmil-images/mine/8eml) | Crystal Structure of Gsx2 Homeodomain in Complex with DNA | Descriptor: | DNA (5'-D(P*GP*AP*GP*CP*TP*AP*AP*TP*TP*AP*AP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*TP*TP*AP*AP*TP*TP*AP*GP*CP*TP*C)-3'), GS homeobox 2, ... | Authors: | Webb, J.A, Kovall, R.A. | Deposit date: | 2022-09-28 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Crystal Structure of Gsx2 Homeodomain in Complex with DNA To Be Published
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4OMO
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![BU of 4omo by Molmil](/molmil-images/mine/4omo) | Crystal structure of the c-Src tyrosine kinase SH3 domain mutant Q128E | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src | Authors: | Camara-Artigas, A, Bacarizo, J. | Deposit date: | 2014-01-27 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Electrostatic Effects in the Folding of the SH3 Domain of the c-Src Tyrosine Kinase: pH-Dependence in 3D-Domain Swapping and Amyloid Formation. Plos One, 9, 2014
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8ENJ
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8ERN
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![BU of 8ern by Molmil](/molmil-images/mine/8ern) | Cyclin-free CDK2 in complex with Cpd21 | Descriptor: | Cyclin-dependent kinase 2, GLYCEROL, N,3-dimethyl-4-({7-[(2S)-2-methylpyrrolidine-1-carbonyl]quinazolin-2-yl}amino)benzene-1-sulfonamide | Authors: | Murray, J.M, Oh, A. | Deposit date: | 2022-10-12 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Cyclin-free CDK2 in complex with Cpd21 To Be Published
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6CXY
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7T8F
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6JO1
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![BU of 6jo1 by Molmil](/molmil-images/mine/6jo1) | Structure of the CYP102A1 Haem Domain with N-(S)-Ibuprofenoyl-L-Phenylalanine | Descriptor: | (2S)-2-[[(2S)-2-[4-(2-methylpropyl)phenyl]propanoyl]amino]-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, DIMETHYL SULFOXIDE, ... | Authors: | Stanfield, J.K, Kasai, C, Sugimoto, H, Shiro, Y, Watanabe, Y, Shoji, O. | Deposit date: | 2019-03-19 | Release date: | 2020-03-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain. Angew.Chem.Int.Ed.Engl., 59, 2020
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5YKS
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7CBX
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5UL6
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![BU of 5ul6 by Molmil](/molmil-images/mine/5ul6) | The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions | Descriptor: | Adapter molecule crk, Proline-rich motif of nonstructural protein 1 of influenza a virus | Authors: | Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H. | Deposit date: | 2017-01-24 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Molecular Mechanisms Underlying the Hijack of Host Proteins by the 1918 Spanish Influenza Virus. ACS Chem. Biol., 12, 2017
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7T8E
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![BU of 7t8e by Molmil](/molmil-images/mine/7t8e) | G93A mutant of human SOD1 in P21 space group | Descriptor: | ACETATE ION, SULFATE ION, Superoxide dismutase [Cu-Zn], ... | Authors: | Amporndanai, K, Hasnain, S.S. | Deposit date: | 2021-12-16 | Release date: | 2023-01-25 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement. Sci Rep, 14, 2024
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8ERD
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![BU of 8erd by Molmil](/molmil-images/mine/8erd) | Cyclin-free CDK2 in complex with Cpd17 | Descriptor: | (2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2S)-2-methylpyrrolidin-1-yl]methanone, Cyclin-dependent kinase 2 | Authors: | Murray, J.M, Oh, A. | Deposit date: | 2022-10-11 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Cyclin-free CDK2 in complex with Cpd17 To Be Published
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4OQS
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![BU of 4oqs by Molmil](/molmil-images/mine/4oqs) | Crystal structure of CYP105AS1 | Descriptor: | CYP105AS1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Leys, D. | Deposit date: | 2014-02-10 | Release date: | 2015-02-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc.Natl.Acad.Sci.USA, 112, 2015
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7T9C
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![BU of 7t9c by Molmil](/molmil-images/mine/7t9c) | Crystal structure of dehaloperoxidase B in complex with thymol | Descriptor: | 5-METHYL-2-(1-METHYLETHYL)PHENOL, Dehaloperoxidase B, GLYCEROL, ... | Authors: | de Serrano, V.S, Ghiladi, R.A, Malewschik, T, Yun, D. | Deposit date: | 2021-12-18 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | The Multifunctional Globin Dehaloperoxidase as a Biocatalyst in the Oxidation of Monoterpenes To Be Published
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6CUK
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4OV2
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4OS3
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![BU of 4os3 by Molmil](/molmil-images/mine/4os3) | Three-dimensional structure of the C65A-W112F double mutant of Human lipocalin-type Prostaglandin D Synthase apo-form | Descriptor: | Prostaglandin-H2 D-isomerase | Authors: | Perduca, M, Bovi, M, Bertinelli, M, Bertini, E, Destefanis, L, Carrizo, M.E, Capaldi, S, Monaco, H.L. | Deposit date: | 2014-02-12 | Release date: | 2014-08-06 | Last modified: | 2014-12-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase. Acta Crystallogr.,Sect.D, 70, 2014
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4OW8
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![BU of 4ow8 by Molmil](/molmil-images/mine/4ow8) | Crystal structure of kinase domain of PknA from Mtb | Descriptor: | GLYCEROL, SULFATE ION, Serine/threonine-protein kinase PknA | Authors: | Ravala, S.K, Singh, S, Yadav, G.S, Karthikeyan, S, Chakraborti, P.K. | Deposit date: | 2014-01-31 | Release date: | 2015-02-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis. Febs J., 282, 2015
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6CVC
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