6OD3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6od3 by Molmil](/molmil-images/mine/6od3) | Human TCF4 C-terminal bHLH domain in Complex with 13-bp Oligonucleotide Containing E-box Sequence | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*AP*TP*AP*CP*AP*CP*GP*TP*GP*TP*AP*T)-3'), ... | Authors: | Horton, J.R, Cheng, X, Yang, J. | Deposit date: | 2019-03-25 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.494 Å) | Cite: | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47, 2019
|
|
6OD5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6od5 by Molmil](/molmil-images/mine/6od5) | Human TCF4 C-terminal bHLH domain in Complex with 12-bp Oligonucleotide Containing E-box Sequence with 5-carboxylcytosines | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*AP*(1CC)P*GP*CP*AP*CP*GP*TP*GP*(1CC)P*G)-3'), ... | Authors: | Horton, J.R, Cheng, X, Yang, J. | Deposit date: | 2019-03-25 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47, 2019
|
|
6OD4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6od4 by Molmil](/molmil-images/mine/6od4) | Human TCF4 C-terminal bHLH domain in Complex with 11-bp Oligonucleotide Containing E-box Sequence | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*TP*AP*CP*AP*CP*GP*TP*GP*TP*A)-3'), Transcription factor 4 | Authors: | Horton, J.R, Cheng, X, Yang, J. | Deposit date: | 2019-03-25 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res., 47, 2019
|
|
4H10
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4h10 by Molmil](/molmil-images/mine/4h10) | |
4F3L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4f3l by Molmil](/molmil-images/mine/4f3l) | Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex | Descriptor: | BMAL1b, Circadian locomoter output cycles protein kaput | Authors: | Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J. | Deposit date: | 2012-05-09 | Release date: | 2012-06-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.268 Å) | Cite: | Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science, 337, 2012
|
|
5Y7Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5y7y by Molmil](/molmil-images/mine/5y7y) | Crystal structure of AhRR/ARNT complex | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor repressor, GLYCEROL | Authors: | Sakurai, S, Shimizu, T, Ohto, U. | Deposit date: | 2017-08-18 | Release date: | 2017-09-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription. J. Biol. Chem., 292, 2017
|
|
6QTV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qtv by Molmil](/molmil-images/mine/6qtv) | |
3U5V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3u5v by Molmil](/molmil-images/mine/3u5v) | Crystal structure of Max-E47 | Descriptor: | NITRATE ION, Protein max, Transcription factor E2-alpha chimera | Authors: | Guarne, A, Ahmadpour, F, Gloyd, M. | Deposit date: | 2011-10-11 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the minimalist max-e47 protein chimera. Plos One, 7, 2012
|
|
5GNJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gnj by Molmil](/molmil-images/mine/5gnj) | Structure of a transcription factor and DNA complex | Descriptor: | DNA (5'-D(*AP*GP*GP*AP*AP*CP*AP*CP*GP*TP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*TP*CP*AP*CP*GP*TP*GP*TP*TP*CP*C)-3'), Transcription factor MYC2 | Authors: | Lian, T, Xu, Y, Su, X. | Deposit date: | 2016-07-21 | Release date: | 2017-05-10 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep, 19, 2017
|
|
5EYO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eyo by Molmil](/molmil-images/mine/5eyo) | The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA | Descriptor: | DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max | Authors: | Wang, D, Hashimoto, H, Zhang, X, Cheng, X. | Deposit date: | 2015-11-25 | Release date: | 2016-12-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. Nucleic Acids Res., 45, 2017
|
|
5NJ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nj8 by Molmil](/molmil-images/mine/5nj8) | |
2MH3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mh3 by Molmil](/molmil-images/mine/2mh3) | NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1 | Descriptor: | Transcription factor HES-1 | Authors: | Wienk, H, Popovic, M, Coglievina, M, Boelens, R, Pongor, S, Pintar, A. | Deposit date: | 2013-11-15 | Release date: | 2014-02-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA. Proteins, 82, 2014
|
|
8OSB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8osb by Molmil](/molmil-images/mine/8osb) | TWIST1-TCF4-ALX4 complex on specific DNA | Descriptor: | DNA (25-MER), Homeobox protein aristaless-like 4, Transcription factor 4, ... | Authors: | Morgunova, E, Kim, S, Popov, A, Wysocka, J, Taipale, J. | Deposit date: | 2023-04-18 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | DNA-guided transcription factor cooperativity shapes face and limb mesenchyme. Cell, 187, 2024
|
|
6QPJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qpj by Molmil](/molmil-images/mine/6qpj) | Human CLOCK PAS-A domain | Descriptor: | Circadian locomoter output cycles protein kaput | Authors: | Kwon, H, Freeman, S.L, Moody, P.C.E, Raven, E.L, Basran, J. | Deposit date: | 2019-02-14 | Release date: | 2019-09-25 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.315 Å) | Cite: | Heme binding to human CLOCK affects interactions with the E-box. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6FX5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fx5 by Molmil](/molmil-images/mine/6fx5) | MITF dimerization mutant | Descriptor: | Microphthalmia-associated transcription factor, SULFATE ION | Authors: | Pogenberg, V, Milewski, M, Wilmanns, M. | Deposit date: | 2018-03-08 | Release date: | 2019-03-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif. Nucleic Acids Res., 48, 2020
|
|
6MGN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mgn by Molmil](/molmil-images/mine/6mgn) | mouse Id1 (51-104) - human hE47 (348-399) complex | Descriptor: | DNA-binding protein inhibitor ID-1, Transcription factor E2-alpha | Authors: | Benezra, R, Pavletich, N.P, Gall, A.-L, Goldgur, Y. | Deposit date: | 2018-09-14 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep, 29, 2019
|
|
1NLW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nlw by Molmil](/molmil-images/mine/1nlw) | Crystal structure of Mad-Max recognizing DNA | Descriptor: | 5'-D(*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3', MAD PROTEIN, MAX PROTEIN | Authors: | Nair, S.K, Burley, S.K. | Deposit date: | 2003-01-07 | Release date: | 2003-02-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors Cell(Cambridge,Mass.), 112, 2003
|
|
1NKP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nkp by Molmil](/molmil-images/mine/1nkp) | Crystal structure of Myc-Max recognizing DNA | Descriptor: | 5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3', Max protein, Myc proto-oncogene protein | Authors: | Nair, S.K, Burley, S.K. | Deposit date: | 2003-01-03 | Release date: | 2003-02-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors Cell(Cambridge,Mass.), 112, 2003
|
|
7D8T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d8t by Molmil](/molmil-images/mine/7d8t) | MITF bHLHLZ complex with M-box DNA | Descriptor: | DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit | Authors: | Guo, M, Fang, P, Wang, J. | Deposit date: | 2020-10-09 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
|
|
7D8S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d8s by Molmil](/molmil-images/mine/7d8s) | MITF bHLHLZ apo structure | Descriptor: | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION | Authors: | Guo, M, Fang, P, Wang, J. | Deposit date: | 2020-10-09 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
|
|
1X0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1x0o by Molmil](/molmil-images/mine/1x0o) | human ARNT C-terminal PAS domain | Descriptor: | Aryl hydrocarbon receptor nuclear translocator | Authors: | Card, P.B, Erbel, P.J, Gardner, K.H. | Deposit date: | 2005-03-25 | Release date: | 2005-10-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural Basis of ARNT PAS-B Dimerization: Use of a Common Beta-sheet Interface for Hetero- and Homodimerization. J.Mol.Biol., 353, 2005
|
|
2A24
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2a24 by Molmil](/molmil-images/mine/2a24) | HADDOCK Structure of HIF-2a/ARNT PAS-B Heterodimer | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain protein 1 | Authors: | Card, P.B, Erbel, P.J, Gardner, K.H. | Deposit date: | 2005-06-21 | Release date: | 2006-01-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization. J.Mol.Biol., 353, 2005
|
|
2K7S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k7s by Molmil](/molmil-images/mine/2k7s) | |
8T2I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8t2i by Molmil](/molmil-images/mine/8t2i) | Negative stain EM assembly of MYC, JAZ, and NINJA complex | Descriptor: | AFP homolog 2, Maltose/maltodextrin-binding periplasmic protein, Protein TIFY 10A, ... | Authors: | Zhou, X.E, Zhang, Y, Zhou, Y, He, Q, Cao, X, Kariapper, L, Suino-Powell, K, Zhu, Y, Zhang, F, Karsten, M. | Deposit date: | 2023-06-06 | Release date: | 2023-06-28 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (10.4 Å) | Cite: | Assembly of JAZ-JAZ and JAZ-NINJA complexes in jasmonate signaling. Plant Commun., 4, 2023
|
|
7W80
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w80 by Molmil](/molmil-images/mine/7w80) | Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan | Descriptor: | 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | Authors: | Ren, X, Diao, X, Zhuang, J, Wu, D. | Deposit date: | 2021-12-07 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.754 Å) | Cite: | Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan. Mol.Pharmacol., 2022
|
|