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7GQT
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BU of 7gqt by Molmil
Crystal Structure of Werner helicase fragment 517-945 in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, MAGNESIUM ION, ...
Authors:Classen, M, Benz, J, Brugger, D, Rudolph, M.G.
Deposit date:2023-10-19
Release date:2024-05-01
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
7GQU
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BU of 7gqu by Molmil
Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ...
Authors:Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G.
Deposit date:2023-10-19
Release date:2024-05-01
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
8QPK
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BU of 8qpk by Molmil
Cryo-EM Structure of Pre-B+5'ss Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-02
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8QPB
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BU of 8qpb by Molmil
Cryo-EM Structure of Pre-B+ATP Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-01
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8QPA
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BU of 8qpa by Molmil
Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-01
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8QP8
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BU of 8qp8 by Molmil
Cryo-EM Structure of Pre-B Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-09-30
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8QP9
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BU of 8qp9 by Molmil
Cryo-EM Structure of Pre-B+AMPPNP Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-09-30
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8QOZ
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BU of 8qoz by Molmil
Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-09-29
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8QO9
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BU of 8qo9 by Molmil
Cryo-EM structure of a human spliceosomal B complex protomer
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2023-09-28
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (5.29 Å)
Cite:New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
8QCB
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BU of 8qcb by Molmil
CryoEM structure of a S. Cerevisiae Ski2387 complex in the open state
Descriptor: Antiviral helicase SKI2, Antiviral protein SKI8, Superkiller protein 3, ...
Authors:Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E.
Deposit date:2023-08-25
Release date:2023-11-08
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
8QCA
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BU of 8qca by Molmil
CryoEM structure of a S. Cerevisiae Ski2387 complex in the closed state bound to RNA
Descriptor: Antiviral helicase SKI2, Antiviral protein SKI8, RNA (5'-R(P*UP*UP*UP*U)-3'), ...
Authors:Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E.
Deposit date:2023-08-25
Release date:2023-11-15
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
8QCF
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BU of 8qcf by Molmil
yeast cytoplasmic exosome-Ski2 complex degrading a RNA substrate
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Antiviral helicase SKI2, Exosome complex component CSL4, ...
Authors:Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E.
Deposit date:2023-08-25
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
8Q9T
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BU of 8q9t by Molmil
CryoEM structure of a S. Cerevisiae Ski238 complex bound to RNA
Descriptor: Antiviral helicase SKI2, Antiviral protein SKI8, RNA (5'-R(P*UP*UP*UP*U)-3'), ...
Authors:Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E.
Deposit date:2023-08-21
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Mol.Cell, 83, 2023
8Q91
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BU of 8q91 by Molmil
Structure of the human 20S U5 snRNP core
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Schneider, S, Galej, W.P.
Deposit date:2023-08-19
Release date:2024-03-27
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
8Q7V
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BU of 8q7v by Molmil
Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Riabov Bassat, D, Plaschka, C, Vorlaender, M.K.
Deposit date:2023-08-17
Release date:2024-04-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
8Q7X
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BU of 8q7x by Molmil
Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Riabov Bassat, D, Plaschka, C, Vorlaender, M.K.
Deposit date:2023-08-17
Release date:2024-04-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
8Q7W
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BU of 8q7w by Molmil
Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Riabov Bassat, D, Plaschka, C, Vorlaender, M.K.
Deposit date:2023-08-17
Release date:2024-04-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
8Q7Q
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BU of 8q7q by Molmil
Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Riabov Bassat, D, Plaschka, C, Vorlaender, M.K.
Deposit date:2023-08-16
Release date:2024-04-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
8PO8
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BU of 8po8 by Molmil
Structure of Escherichia coli HrpA in complex with ADP and oligonucleotide poly(dC)11 forming an i-motif
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase HrpA, DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), ...
Authors:Xin, B.G, Yuan, L.G, Zhang, L.L, Xie, S.M, Liu, N.N, Ai, X, Li, H.H, Rety, S, Xi, X.G.
Deposit date:2023-07-03
Release date:2024-05-08
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
Nucleic Acids Res., 52, 2024
8PO6
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BU of 8po6 by Molmil
Structure of Escherichia coli HrpA apo form
Descriptor: ATP-dependent RNA helicase HrpA, PHOSPHATE ION
Authors:Xin, B.G, Yuan, L.G, Zhang, L.L, Xie, S.M, Liu, N.N, Ai, X, Li, H.H, Rety, S, Xi, X.G.
Deposit date:2023-07-03
Release date:2024-05-08
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
Nucleic Acids Res., 52, 2024
8PO7
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BU of 8po7 by Molmil
Structure of Escherichia coli HrpA in complex with ADP and dinucleotide dCdC
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase HrpA, DNA (5'-D(P*CP*C)-3'), ...
Authors:Xin, B.G, Yuan, L.G, Zhang, L.L, Xie, S.M, Liu, N.N, Ai, X, Li, H.H, Rety, S, Xi, X.G.
Deposit date:2023-07-03
Release date:2024-05-08
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
Nucleic Acids Res., 52, 2024
8PNK
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BU of 8pnk by Molmil
Crystal structure of the Ded1p RecA1 domain
Descriptor: ATP-dependent RNA helicase DED1
Authors:Huebner, J, Sprangers, R.
Deposit date:2023-06-30
Release date:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Ded1p RecA1 domain
To Be Published
8TBX
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BU of 8tbx by Molmil
Crystal structure of human DDX1 helicase in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX1, MAGNESIUM ION, ...
Authors:Zeng, H, Dong, A, Li, Y, Yen, H, Hejazi, Z, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L.
Deposit date:2023-06-29
Release date:2023-07-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structure of human DDX1 helicase in complex with ADP
To be published
8PJB
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BU of 8pjb by Molmil
Cryo-EM structure of MLE in complex with UUC RNA and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Dosage compensation regulator, MAGNESIUM ION, ...
Authors:Jagtap, P.K.A, Hennig, J.
Deposit date:2023-06-23
Release date:2023-11-01
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless.
Mol.Cell, 83, 2023
8PJJ
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BU of 8pjj by Molmil
Cryo-EM structure of MLE in complex with SL7UUC RNA and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Dosage compensation regulator, SL7UUC RNA
Authors:Jagtap, P.K.A, Hennig, J.
Deposit date:2023-06-23
Release date:2023-11-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless.
Mol.Cell, 83, 2023

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數據於2024-06-12公開中

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