PDB: 13252 resultsInfo pagesStatus searchChemie searchBIRD

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6CR5	Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CH2-beta, gamma dATP analogue Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]adenosine, DNA polymerase beta, Downstream Primer Strand, ... Authors: Batra, V.K, Wilson, S.H. Deposit date: 2018-03-16 Release date: 2018-07-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.982 Å) Cite: Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry, 57, 2018
7QTT	Structural organization of a late activated human spliceosome (Baqr, core region) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... Authors: Cretu, C, Pena, V. Deposit date: 2022-01-15 Release date: 2023-05-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of catalytic activation in human splicing. Nature, 617, 2023
6ICZ	Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhang, X, Zhan, X, Yan, C, Shi, Y. Deposit date: 2018-09-07 Release date: 2019-03-13 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
7W59	The cryo-EM structure of human pre-C*-I complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W5B	The cryo-EM structure of human C* complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W5A	The cryo-EM structure of human pre-C*-II complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
6ID0	Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... Authors: Zhang, X, Zhan, X, Yan, C, Shi, Y. Deposit date: 2018-09-07 Release date: 2019-03-13 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
8CH6	Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex). Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... Authors: Cretu, C, Schmitzova, J, Pena, V. Deposit date: 2023-02-07 Release date: 2023-05-10 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (5.9 Å) Cite: Structural basis of catalytic activation in human splicing. Nature, 617, 2023
5EG8	The cap binding site of influenza virus protein PB2 as a drug target Descriptor: Polymerase basic protein 2, THIOCYANATE ION Authors: Liu, Y, Zheng, X, Severin, C, Rocha de Moura, T, Li, K, Luo, M. Deposit date: 2015-10-26 Release date: 2016-02-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.54 Å) Cite: The cap-binding site of influenza virus protein PB2 as a drug target. Acta Crystallogr D Struct Biol, 72, 2016
4KHU	Ternary complex of rb69 mutant L415F with a ribonucleotide at -1 position Descriptor: CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*C)-3'), DNA polymerase, ... Authors: Clausen, A.R, Pedersen, L.C. Deposit date: 2013-05-01 Release date: 2013-10-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc.Natl.Acad.Sci.USA, 110, 2013
4KHW	Ternary complex of RB69 mutant L415F with ribonucleotide at -2 position Descriptor: CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*C)-3'), DNA polymerase, ... Authors: Clausen, A.R, Pedersen, L.C. Deposit date: 2013-05-01 Release date: 2013-10-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.371 Å) Cite: Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc.Natl.Acad.Sci.USA, 110, 2013
4KI6	Ternary complex of rb69 mutant l415f with ribonucleotides at -1 and -2 position Descriptor: CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*C)-3'), DNA polymerase, ... Authors: Clausen, A.R, Pedersen, L.C. Deposit date: 2013-05-01 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc.Natl.Acad.Sci.USA, 110, 2013
4KHY	Ternary complex of rb69 mutant L415F with ribonucleotide at -3 position Descriptor: CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*C)-3'), DNA polymerase, ... Authors: Clausen, A.R, Pedersen, L.C. Deposit date: 2013-05-01 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc.Natl.Acad.Sci.USA, 110, 2013
4KI4	Ternary complex of rb69 mutant L415F with ribonucleotides at 0 and -1 position Descriptor: CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*C)-3'), DNA polymerase, ... Authors: Clausen, A.R, Pedersen, L.C. Deposit date: 2013-05-01 Release date: 2013-10-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc.Natl.Acad.Sci.USA, 110, 2013
4KHS	Ternary complex of RB69 mutant L415F with a ribonucleotide at 0 position Descriptor: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*C)-3'), ... Authors: Clausen, A.R, Pedersen, L.C. Deposit date: 2013-05-01 Release date: 2013-10-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proc.Natl.Acad.Sci.USA, 110, 2013
5YVG	Crystal structure of Karyopherin beta2 in complex with FUS(full length) Descriptor: RNA-binding protein FUS, Transportin-1 Authors: Yoshizawa, T, Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-11-25 Release date: 2018-05-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (4.05 Å) Cite: Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173, 2018
1NBS	Crystal structure of the specificity domain of Ribonuclease P RNA Descriptor: LEAD (II) ION, MAGNESIUM ION, RIBONUCLEASE P RNA Authors: Krasilnikov, A.S, Yang, X, Pan, T, Mondragon, A. Deposit date: 2002-12-03 Release date: 2003-02-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Crystal structure of the specificity domain of Ribonuclease P Nature, 421, 2003
8Q7W	Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. Deposit date: 2023-08-17 Release date: 2024-04-17 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of human U5 snRNP late biogenesis and recycling. Nat.Struct.Mol.Biol., 31, 2024
8Q7X	Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. Deposit date: 2023-08-17 Release date: 2024-04-17 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structural basis of human U5 snRNP late biogenesis and recycling. Nat.Struct.Mol.Biol., 31, 2024
8Q7Q	Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. Deposit date: 2023-08-16 Release date: 2024-04-17 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis of human U5 snRNP late biogenesis and recycling. Nat.Struct.Mol.Biol., 31, 2024
8Q7V	Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. Deposit date: 2023-08-17 Release date: 2024-04-17 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis of human U5 snRNP late biogenesis and recycling. Nat.Struct.Mol.Biol., 31, 2024
6GP9	Structural studies of hepatitis C virus non-structural protein-5b of genotype 4a Descriptor: RNA-directed RNA polymerase Authors: Janowski, R, Geber, H, Protzer, U, Niessing, D. Deposit date: 2018-06-05 Release date: 2020-09-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural studies of hepatitis C virus non-structural protein-5b of genotype 4a Biorxiv, 2022
1NVP	HUMAN TFIIA/TBP/DNA COMPLEX Descriptor: 5'-D(*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*CP*CP*CP*C)-3', 5'-D(*GP*GP*GP*GP*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*G)-3', TATA box binding protein, ... Authors: Bleichenbacher, M, Tan, S, Richmond, T.J. Deposit date: 2003-02-04 Release date: 2003-10-21 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J.Mol.Biol., 332, 2003
7AQO	yeast THO-Sub2 complex dimer Descriptor: BJ4_G0025130.mRNA.1.CDS.1, EM14S01-3B_G0007820.mRNA.1.CDS.1, TEX1 isoform 1, ... Authors: Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. Deposit date: 2020-10-22 Release date: 2020-12-02 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife, 9, 2020
1NH2	Crystal structure of a yeast TFIIA/TBP/DNA complex Descriptor: 5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3', 5'-D(*TP*GP*TP*AP*(5IU)P*GP*TP*AP*TP*AP*(5IU)P*AP*AP*AP*AP*C)-3', Transcription initiation factor IIA large chain, ... Authors: Bleichenbacher, M, Tan, S, Richmond, T.J. Deposit date: 2002-12-18 Release date: 2003-10-21 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J.Mol.Biol., 332, 2003

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