4LQT
| 1.10A resolution crystal structure of a superfolder green fluorescent protein (W57A) mutant | Descriptor: | 1,2-ETHANEDIOL, Green fluorescent protein | Authors: | Lovell, S, Xia, Y, Vo, B, Battaile, K.P, Egan, C, Karanicolas, J. | Deposit date: | 2013-07-19 | Release date: | 2013-12-18 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation. J.Am.Chem.Soc., 135, 2013
|
|
4JLZ
| |
4JK5
| Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Ser) | Descriptor: | 1,3,5-tris(bromomethyl)benzene, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... | Authors: | Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. | Deposit date: | 2013-03-09 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids. Chembiochem, 14, 2013
|
|
4JJR
| |
4LR2
| Crystal Structure of Human ENPP4 (apo) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bis(5'-adenosyl)-triphosphatase ENPP4, ... | Authors: | Albright, R.A, Braddock, D.T. | Deposit date: | 2013-07-19 | Release date: | 2013-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J.Biol.Chem., 289, 2014
|
|
1SGF
| CRYSTAL STRUCTURE OF 7S NGF: A COMPLEX OF NERVE GROWTH FACTOR WITH FOUR BINDING PROTEINS (SERINE PROTEINASES) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NERVE GROWTH FACTOR, ... | Authors: | Bax, B.D.V, Blundell, T.L, Murray-Rust, J, Mcdonald, N.Q. | Deposit date: | 1997-08-08 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure, 5, 1997
|
|
1SHL
| CASPASE-7 IN COMPLEX WITH FICA ALLOSTERIC INHIBITOR | Descriptor: | 5-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID-(2-MERCAPTO-ETHYL)-AMIDE, Caspase-7 | Authors: | Hardy, J.A, Lam, J, Nguyen, J.T, O'Brien, T, Wells, J.A. | Deposit date: | 2004-02-25 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of an allosteric site in the caspases Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
4KAI
| HCV NS5B GT1B N316 with GSK5852A | Descriptor: | HCV Polymerase, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid | Authors: | Williams, S.P, Kahler, K.M, Shotwell, J.B. | Deposit date: | 2013-04-22 | Release date: | 2013-05-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
|
|
4KE5
| HCV NS5B GT1B N316Y with GSK5852 | Descriptor: | HCV Polymerase, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid | Authors: | Williams, S.P, Kahler, K.M, Shotwell, J.B. | Deposit date: | 2013-04-25 | Release date: | 2013-05-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
|
|
4KEJ
| |
1TBQ
| |
4M14
| |
4MA7
| Crystal structure of mouse prion protein complexed with Promazine | Descriptor: | Major prion protein, POM1 heavy chain, POM1 light chain, ... | Authors: | Baral, P.K, Swayampakula, M, James, M.N.G. | Deposit date: | 2013-08-15 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural basis of prion inhibition by phenothiazine compounds. Structure, 22, 2014
|
|
1UIO
| ADENOSINE DEAMINASE (HIS 238 ALA MUTANT) | Descriptor: | 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION | Authors: | Wilson, D.K, Quiocho, F.A. | Deposit date: | 1996-08-30 | Release date: | 1997-06-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996
|
|
4LQI
| Yeast 20S Proteasome in complex with Vibralactone | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | Authors: | List, A, Zeiler, E, Gallastegui, N, Rusch, M, Hedberg, C, Sieber, S.A, Groll, M. | Deposit date: | 2013-07-18 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Omuralide and Vibralactone: Differences in the Proteasome-beta-Lactone-gamma-Lactam Binding Scaffold Alter Target Preferences. Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
4M15
| |
4M0Y
| |
4MA8
| Crystal structure of mouse prion protein complexed with Chlorpromazine | Descriptor: | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, Major prion protein, POM1 heavy chain, ... | Authors: | Baral, P.K, Swayampakula, M, James, M.N.G. | Deposit date: | 2013-08-15 | Release date: | 2014-01-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of prion inhibition by phenothiazine compounds. Structure, 22, 2014
|
|
4LQU
| 1.60A resolution crystal structure of a superfolder green fluorescent protein (W57G) mutant | Descriptor: | Green fluorescent protein | Authors: | Lovell, S, Xia, Y, Vo, B, Battaile, K.P, Egan, C, Karanicolas, J. | Deposit date: | 2013-07-19 | Release date: | 2013-12-18 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation. J.Am.Chem.Soc., 135, 2013
|
|
4LPH
| Crystal structure of human FPPS in complex with CL03093 | Descriptor: | ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl)phosphonic acid, Farnesyl pyrophosphate synthase, PHOSPHATE ION | Authors: | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2013-07-16 | Release date: | 2014-06-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. J.Med.Chem., 57, 2014
|
|
4M13
| |
4LV4
| A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase | Descriptor: | 8-hydroxyquinoline-2-carboxylic acid, ACETATE ION, Fructose-bisphosphate aldolase, ... | Authors: | Capodagli, G.C, Pegan, S.D. | Deposit date: | 2013-07-25 | Release date: | 2014-01-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | A Noncompetitive Inhibitor for Mycobacterium tuberculosis's Class IIa Fructose 1,6-Bisphosphate Aldolase. Biochemistry, 53, 2014
|
|
4M12
| |
3ZTT
| Crystal structure of pneumococcal surface antigen PsaA with manganese | Descriptor: | MANGANESE (II) ION, MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN | Authors: | McDevitt, C.A, Ogunniyi, A.D, Valkov, E, Lawrence, M.C, Kobe, B, McEwan, A.G, Paton, J.C. | Deposit date: | 2011-07-12 | Release date: | 2011-12-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathog., 7, 2011
|
|
3ZR8
| Crystal structure of RxLR effector Avr3a11 from Phytophthora capsici | Descriptor: | AVR3A11, CHLORIDE ION, TRIETHYLENE GLYCOL | Authors: | Boutemy, L.S, King, S.R.F, Win, J, Hughes, R.K, Clarke, T.A, Blumenschein, T.M.A, Kamoun, S, Banfield, M.J. | Deposit date: | 2011-06-15 | Release date: | 2011-08-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Structures of Phytophthora Rxlr Effector Proteins: A Conserved But Adaptable Fold Underpins Functional Diversity. J.Biol.Chem., 286, 2011
|
|