Crystal structure of mouse prion protein complexed with Chlorpromazine

Summary for 4MA8

DescriptorMajor prion protein, POM1 heavy chain, POM1 light chain, ... (5 entities in total)
Functional Keywordsimmunoglobulin fold, fab, antibody, mouse prion protein, immune system
Biological sourceMus musculus (mouse)
Cellular locationCell membrane; Lipid-anchor, GPI-anchor (By similarity) P04925
Total number of polymer chains3
Total molecular weight60586.52
Baral, P.K.,Swayampakula, M.,James, M.N.G. (deposition date: 2013-08-15, release date: 2014-01-22, Last modification date: 2014-02-26)
Primary citation
Baral, P.K.,Swayampakula, M.,Rout, M.K.,Kav, N.N.,Spyracopoulos, L.,Aguzzi, A.,James, M.N.
Structural basis of prion inhibition by phenothiazine compounds.
Structure, 22:291-303, 2014
PubMed: 24373770 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2013.11.009
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24171.3%5.3%5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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