4JJR
A P21 crystal form of mammalian casein kinase 1 delta
Summary for 4JJR
| Entry DOI | 10.2210/pdb4jjr/pdb |
| Descriptor | Casein kinase I isoform delta (2 entities in total) |
| Functional Keywords | ck1d, kinase, casein kinase, transferase |
| Biological source | Mus musculus (mouse) |
| Cellular location | Cytoplasm (By similarity): Q9DC28 |
| Total number of polymer chains | 2 |
| Total formula weight | 69452.21 |
| Authors | Zeringo, N.A.,Bellizzi, J.J. (deposition date: 2013-03-08, release date: 2013-06-12, Last modification date: 2023-09-20) |
| Primary citation | Zeringo, N.A.,Murphy, L.,McCloskey, E.A.,Rohal, L.,Bellizzi, J.J. A monoclinic crystal form of casein kinase 1 delta Acta Crystallogr.,Sect.F, 69:1077-1083, 2013 Cited by PubMed Abstract: Casein kinase 1 δ (CK1δ) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1δ have previously been determined and this article reports the crystallization and structure determination of a new crystal form belonging to space group P21. Comparison of CK1δ crystal structures reveals few conformational differences within the C-terminal lobe, but more significant movements of the β-sheet region of the N-terminal lobe were observed. PubMed: 24100552DOI: 10.1107/S1744309113023403 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4078 Å) |
Structure validation
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