4M12
Crystal structure of ITK in complex with compound 7 [4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide]
Summary for 4M12
Entry DOI | 10.2210/pdb4m12/pdb |
Related | 4M0Y 4M0Z 4M13 4M14 4M15 |
Descriptor | Tyrosine-protein kinase ITK/TSK, 4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q08881 |
Total number of polymer chains | 1 |
Total formula weight | 30988.35 |
Authors | Han, S.,Caspers, N.L. (deposition date: 2013-08-02, release date: 2014-04-02, Last modification date: 2024-02-28) |
Primary citation | Han, S.,Czerwinski, R.M.,Caspers, N.L.,Limburg, D.C.,Ding, W.,Wang, H.,Ohren, J.F.,Rajamohan, F.,McLellan, T.J.,Unwalla, R.,Choi, C.,Parikh, M.D.,Seth, N.,Edmonds, J.,Phillips, C.,Shakya, S.,Li, X.,Spaulding, V.,Hughes, S.,Cook, A.,Robinson, C.,Mathias, J.P.,Navratilova, I.,Medley, Q.G.,Anderson, D.R.,Kurumbail, R.G.,Aulabaugh, A. Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors. Biochem.J., 460:211-222, 2014 Cited by PubMed: 24593284DOI: 10.1042/BJ20131139 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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