PDB: 55616 resultsInfo pagesStatus searchChemie searchBIRD

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4BQD	KD1 of human TFPI in complex with a synthetic peptide Descriptor: GLYCEROL, PEPTIDE, TISSUE FACTOR PATHWAY INHIBITOR (LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR) VARIANT Authors: Griessner, A, Brandstetter, H. Deposit date: 2013-05-30 Release date: 2013-12-04 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor Viia by Tissue Factor Pathway Inhibitor (Tfpi) J.Biol.Chem., 289, 2014
3N0P	A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor Descriptor: CHLORIDE ION, Prolactin, Prolactin receptor, ... Authors: Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. Deposit date: 2010-05-14 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
5OIM	InhA (T2A mutant) complexed with ethyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-6-carboxylate Descriptor: 2-ETHOXYETHANOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Convery, M.A. Deposit date: 2017-07-19 Release date: 2018-02-14 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem, 13, 2018
3S3W	Structure of chicken acid-sensing ion channel 1 at 2.6 a resolution and ph 7.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive cation channel 2, ... Authors: Dawson, R.J.P, Benz, J, Stohler, P, Tetaz, T, Joseph, C, Huber, S, Schmid, G, Huegin, D, Pflimlin, P, Trube, G, Rudolph, M.G, Hennig, M, Ruf, A. Deposit date: 2011-05-18 Release date: 2012-05-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1. Nat Commun, 3, 2012
2E59	Crystal structure of human MD-2 in complex with lipid IVa Descriptor: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-4-O-phosphono-beta-D-glucopyranose, ... Authors: Ohto, U, Satow, Y. Deposit date: 2006-12-19 Release date: 2007-06-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa Science, 316, 2007
4CMH	Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984 Descriptor: ADP-RIBOSYL CYCLASE 1, HEAVY CHAIN OF SAR650984-FAB FRAGMENT, LIGHT CHAIN OF SAR650984-FAB FRAGMENT Authors: Deckert, J, Wetzel, M.C, Park, P.U, Bartle, L.M, Skaletskaya, A, Goldmacher, V, Vallee, F, ZhouLiu, Q, Ferrari, P, Pouzieux, S, Lahoute, C, Dumontet, C, Plesa, A, Chiron, M, Lejeune, P, Chittenden, T, Blanc, V. Deposit date: 2014-01-15 Release date: 2014-07-16 Last modified: 2018-10-24 Method: X-RAY DIFFRACTION (1.53 Å) Cite: SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies. Clin. Cancer Res., 20, 2014
6R28	Structure of peptide P7, which binds Cdc42 and inhibits effector interactions. Descriptor: peptide P7 Authors: Murphy, N.P, Mott, H.R, Owen, D. Deposit date: 2019-03-15 Release date: 2020-01-29 Last modified: 2024-03-06 Method: SOLUTION NMR Cite: The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling. J.Biol.Chem., 295, 2020
3NCE	A mutant human Prolactin receptor antagonist H27A in complex with the mutant extracellular domain H188A of the human prolactin receptor Descriptor: CARBONATE ION, CHLORIDE ION, Prolactin, ... Authors: Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. Deposit date: 2010-06-04 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
2HK4	Dimeric solution structure of the cyclic octamer d(CCGTCCGT) Descriptor: 5'-D(P*CP*CP*GP*TP*CP*CP*GP*T)-3' Authors: Escaja, N, Gomez-Pinto, I, Pedroso, E, Gonzalez, C. Deposit date: 2006-07-03 Release date: 2007-03-20 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Four-stranded DNA structures can be stabilized by two different types of minor groove G:C:G:C tetrads. J.Am.Chem.Soc., 129, 2007
1CQN	PROTEIN AGGREGATION AND ALZHEIMER'S DISEASE: CRYSTALLOGRAPHIC ANALYSIS OF THE PHENOMENON. ENGINEERED VERSION OF THE RIBOSOMAL PROTEIN S6 USED AS A STABLE SCAFFOLD TO STUDY OLIGOMERIZATION. Descriptor: RIBOSOMAL PROTEIN S6 Authors: Kristensen, O, Otzen, D.E, Oliveberg, M. Deposit date: 1999-08-08 Release date: 2000-09-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: a structural clue to amyloid assembly. Proc.Natl.Acad.Sci.USA, 97, 2000
1D83	STRUCTURE REFINEMENT OF THE CHROMOMYCIN DIMER/DNA OLIGOMER COMPLEX IN SOLUTION Descriptor: (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... Authors: Gao, X, Mirau, P, Patel, D.J. Deposit date: 1992-07-22 Release date: 1993-07-15 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure refinement of the chromomycin dimer-DNA oligomer complex in solution. J.Mol.Biol., 223, 1992
1CQM	PROTEIN AGGREGATION AND ALZHEIMER'S DISEASE: CRYSTALLOGRAPHIC ANALYSIS OF THE PHENOMENON. ENGINEERED VERSION OF THE RIBOSOMAL PROTEIN S6 USED AS A STABLE SCAFFOLD TO STUDY OLIGOMERIZATION. Descriptor: RIBOSOMAL PROTEIN S6 Authors: Kristensen, O, Otzen, D.E, Oliveberg, M. Deposit date: 1999-08-08 Release date: 2000-09-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: a structural clue to amyloid assembly. Proc.Natl.Acad.Sci.USA, 97, 2000
3NCC	A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor Descriptor: CARBONATE ION, CHLORIDE ION, Prolactin, ... Authors: Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. Deposit date: 2010-06-04 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
2OPT	Crystal Structure of Apo ActR from Streptomyces coelicolor. Descriptor: ActII protein Authors: Willems, A.R, Junop, M.S. Deposit date: 2007-01-30 Release date: 2008-02-05 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA. J.Mol.Biol., 376, 2008
4BK6	Crystal Structure of a dimeric variant of Bet v 1 Descriptor: MAJOR POLLEN ALLERGEN BET V 1-A Authors: Kofler, S.G, Brandstetter, H. Deposit date: 2013-04-22 Release date: 2013-11-27 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Stabilization of the Dimeric Birch Pollen Allergen Bet V 1 Impacts its Immunological Properties J.Biol.Chem., 289, 2014
2OM9	Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma Descriptor: (6AR,10AR)-3-(1,1-DIMETHYLHEPTYL)-1-HYDROXY-6,6-DIMETHYL-6A,7,10,10A-TETRAHYDRO-6H-BENZO[C]CHROMENE-9-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma Authors: Ambrosio, A.L.B, Garratt, R.C. Deposit date: 2007-01-21 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Ajulemic Acid, a Synthetic Nonpsychoactive Cannabinoid Acid, Bound to the Ligand Binding Domain of the Human Peroxisome Proliferator-activated Receptor gamma J.Biol.Chem., 282, 2007
3NCB	A mutant human Prolactin receptor antagonist H180A in complex with the extracellular domain of the human prolactin receptor Descriptor: CARBONATE ION, CHLORIDE ION, Prolactin, ... Authors: Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. Deposit date: 2010-06-04 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
3NCF	A mutant human Prolactin receptor antagonist H30A in complex with the mutant extracellular domain H188A of the human prolactin receptor Descriptor: CHLORIDE ION, Prolactin, Prolactin receptor, ... Authors: Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. Deposit date: 2010-06-04 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
4BTZ	Crystal Structure of peroxinitrite treated Major Birch Pollen Allergen Bet v 1.0101 (isoform a) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR POLLEN ALLERGEN BET V 1-A Authors: Kofler, S.G, Ackaert, C, Brandstetter, H. Deposit date: 2013-06-19 Release date: 2014-07-02 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.47 Å) Cite: The Crystal Structure of the Major Birch Pollen Allergen Bet V 1 After Nitration with Peroxinitrite To be Published
2OBF	Structure of K57A hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy (SAH) Descriptor: (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE Authors: Drinkwater, N, Martin, J.L. Deposit date: 2006-12-19 Release date: 2007-10-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007
4BPW	Crystal structure of human primase bound to UTP Descriptor: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, MAGNESIUM ION, ... Authors: Kilkenny, M.L, Perera, R.L, Pellegrini, L. Deposit date: 2013-05-28 Release date: 2013-09-25 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.003 Å) Cite: Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering Proc.Natl.Acad.Sci.USA, 110, 2013
7UN8	SfSTING with c-di-GMP single fiber Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CD-NTase-associated protein 12 Authors: Morehouse, B.R, Yip, M.C.J, Keszei, A.F.A, McNamara-Bordewick, N.K, Shao, S, Kranzusch, P.J. Deposit date: 2022-04-09 Release date: 2022-07-27 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM structure of an active bacterial TIR-STING filament complex. Nature, 608, 2022
7UN9	SfSTING with c-di-GMP double fiber Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CD-NTase-associated protein 12 Authors: Morehouse, B.R, Yip, M.C.J, Keszei, A.F.A, McNamara-Bordewick, N.K, Shao, S, Kranzusch, P.J. Deposit date: 2022-04-09 Release date: 2022-07-27 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM structure of an active bacterial TIR-STING filament complex. Nature, 608, 2022
7UNA	SfSTING with cGAMP (masked) Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CD-NTase-associated protein 12 Authors: Morehouse, B.R, Yip, M.C.J, Keszei, A.F.A, McNamara-Bordewick, N.K, Shao, S, Kranzusch, P.J. Deposit date: 2022-04-09 Release date: 2022-07-27 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (4 Å) Cite: Cryo-EM structure of an active bacterial TIR-STING filament complex. Nature, 608, 2022
2ONY	Structure of hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy Descriptor: N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, PHOSPHATE ION, Phenylethanolamine N-methyltransferase, ... Authors: Drinkwater, N, Martin, J.L. Deposit date: 2007-01-24 Release date: 2007-10-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007

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