2E59

Crystal structure of human MD-2 in complex with lipid IVa

Summary for 2E59

Related2E56
DescriptorLymphocyte antigen 96, N-ACETYL-D-GLUCOSAMINE, (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, ... (5 entities in total)
Functional Keywordsinnate immunity, lipid-binding, lipid binding protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space Q9Y6Y9
Total number of polymer chains1
Total molecular weight18452.27
Authors
Ohto, U.,Satow, Y. (deposition date: 2006-12-19, release date: 2007-06-26, Last modification date: 2011-07-13)
Primary citation
Ohto, U.,Fukase, K.,Miyake, K.,Satow, Y.
Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
Science, 316:1632-1634, 2007
PubMed: 17569869 (PDB entries with the same primary citation)
DOI: 10.1126/science.1139111
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.21 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.261160.7%4.5%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2e59
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