7UNA

SfSTING with cGAMP (masked)

Summary for 7UNA

• Entry DOI: 10.2210/pdb7una/pdb
• Related: 7UN8
• EMDB information: 26618
• Descriptor: CD-NTase-associated protein 12, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one (2 entities in total)
• Functional Keywords: sting, bacterial, filament, antiviral protein
• Biological source: Sphingobacterium faecium
• Total number of polymer chains: 8
• Total formula weight: 298346.05

Authors

Morehouse, B.R.,Yip, M.C.J.,Keszei, A.F.A.,McNamara-Bordewick, N.K.,Shao, S.,Kranzusch, P.J. (deposition date: 2022-04-09, release date: 2022-07-27, Last modification date: 2024-02-14)

• Primary citation: Morehouse, B.R.,Yip, M.C.J.,Keszei, A.F.A.,McNamara-Bordewick, N.K.,Shao, S.,Kranzusch, P.J.; Cryo-EM structure of an active bacterial TIR-STING filament complex.; Nature, 608:803-807, 2022; PubMed: 35859168; DOI: 10.1038/s41586-022-04999-1

Experimental method

ELECTRON MICROSCOPY (4 Å)