7UN9

SfSTING with c-di-GMP double fiber

Summary for 7UN9

• Entry DOI: 10.2210/pdb7un9/pdb
• Related: 7UN8
• EMDB information: 26616 26617
• Descriptor: CD-NTase-associated protein 12, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) (2 entities in total)
• Functional Keywords: sting, bacterial, filament, antiviral protein
• Biological source: Sphingobacterium faecium
• Total number of polymer chains: 12
• Total formula weight: 415773.31

Authors

Morehouse, B.R.,Yip, M.C.J.,Keszei, A.F.A.,McNamara-Bordewick, N.K.,Shao, S.,Kranzusch, P.J. (deposition date: 2022-04-09, release date: 2022-07-27, Last modification date: 2024-02-14)

• Primary citation: Morehouse, B.R.,Yip, M.C.J.,Keszei, A.F.A.,McNamara-Bordewick, N.K.,Shao, S.,Kranzusch, P.J.; Cryo-EM structure of an active bacterial TIR-STING filament complex.; Nature, 608:803-807, 2022; PubMed: 35859168; DOI: 10.1038/s41586-022-04999-1

Experimental method

ELECTRON MICROSCOPY (3.3 Å)