4CMH
Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984
Summary for 4CMH
Entry DOI | 10.2210/pdb4cmh/pdb |
Descriptor | ADP-RIBOSYL CYCLASE 1, HEAVY CHAIN OF SAR650984-FAB FRAGMENT, LIGHT CHAIN OF SAR650984-FAB FRAGMENT, ... (4 entities in total) |
Functional Keywords | hydrolase-immune system complex, multiple myeloma, hydrolase/immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 78232.60 |
Authors | Deckert, J.,Wetzel, M.C.,Park, P.U.,Bartle, L.M.,Skaletskaya, A.,Goldmacher, V.,Vallee, F.,ZhouLiu, Q.,Ferrari, P.,Pouzieux, S.,Lahoute, C.,Dumontet, C.,Plesa, A.,Chiron, M.,Lejeune, P.,Chittenden, T.,Blanc, V. (deposition date: 2014-01-15, release date: 2014-07-16, Last modification date: 2024-10-09) |
Primary citation | Deckert, J.,Wetzel, M.C.,Bartle, L.M.,Skaletskaya, A.,Goldmacher, V.S.,Vallee, F.,Zhou-Liu, Q.,Ferrari, P.,Pouzieux, S.,Lahoute, C.,Dumontet, C.,Plesa, A.,Chiron, M.,Lejeune, P.,Chittenden, T.,Park, P.U.,Blanc, V. SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies. Clin. Cancer Res., 20:4574-4583, 2014 Cited by PubMed: 24987056DOI: 10.1158/1078-0432.CCR-14-0695 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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