4CMH

Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984

Summary for 4CMH

Entry DOI	10.2210/pdb4cmh/pdb
Descriptor	ADP-RIBOSYL CYCLASE 1, HEAVY CHAIN OF SAR650984-FAB FRAGMENT, LIGHT CHAIN OF SAR650984-FAB FRAGMENT, ... (4 entities in total)
Functional Keywords	hydrolase-immune system complex, multiple myeloma, hydrolase/immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	78232.60
Authors	Deckert, J.,Wetzel, M.C.,Park, P.U.,Bartle, L.M.,Skaletskaya, A.,Goldmacher, V.,Vallee, F.,ZhouLiu, Q.,Ferrari, P.,Pouzieux, S.,Lahoute, C.,Dumontet, C.,Plesa, A.,Chiron, M.,Lejeune, P.,Chittenden, T.,Blanc, V. (deposition date: 2014-01-15, release date: 2014-07-16, Last modification date: 2018-10-24)
Primary citation	Deckert, J.,Wetzel, M.C.,Bartle, L.M.,Skaletskaya, A.,Goldmacher, V.S.,Vallee, F.,Zhou-Liu, Q.,Ferrari, P.,Pouzieux, S.,Lahoute, C.,Dumontet, C.,Plesa, A.,Chiron, M.,Lejeune, P.,Chittenden, T.,Park, P.U.,Blanc, V. SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies. Clin. Cancer Res., 20:4574-4583, 2014 Cited by PubMed: 24987056 DOI: 10.1158/1078-0432.CCR-14-0695 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation