4CMH
Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADP-RIBOSYL CYCLASE 1 | polymer | 256 | 29676.7 | 1 | UniProt (P28907) Pfam (PF02267) | Homo sapiens | CYCLIC ADP-RIBOSE HYDROLASE 1, CADPR HYDROLASE 1, T10, CD38, ACYL-RIBOSE CYCLASE 1 |
| 2 | B (B) | HEAVY CHAIN OF SAR650984-FAB FRAGMENT | polymer | 234 | 25042.8 | 1 | MUS MUSCULUS (HOUSE MOUSE) | ||
| 3 | C (C) | LIGHT CHAIN OF SAR650984-FAB FRAGMENT | polymer | 214 | 23513.1 | 1 | MUS MUSCULUS (HOUSE MOUSE) | ||
| 4 | D, E, F (A, B, C) | water | water | 18.0 | 590 | Chemie (HOH) |
Sequence modifications
A: 45 - 300 (UniProt: P28907)
| PDB | External Database | Details |
|---|---|---|
| Asp 100 | Asn 100 | engineered mutation |
| Ala 164 | Asn 164 | engineered mutation |
| Asp 209 | Asn 209 | engineered mutation |
| Asp 219 | Asn 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 78232.6 | |
| All* | Total formula weight | 78232.6 |
