4CMH

Crystal structure of CD38 with a novel CD38-targeting antibody SAR650984

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID29
Synchrotron site	ESRF
Beamline	ID29
Temperature [K]	100
Detector technology	CCD
Collection date	2009-11-30
Detector	ADSC CCD
Spacegroup name	P 21 21 21
Unit cell lengths	43.619, 111.492, 147.877
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	26.210 - 1.530
R-factor	0.1889
Rwork	0.188
R-free	0.20820
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.010
RMSD bond angle	1.070
Refinement software	BUSTER (2.11.4)

Data quality characteristics

	Overall
Low resolution limit [Å]	26.210
High resolution limit [Å]	1.530
Rmerge	0.090
Number of reflections	109141
Completeness [%]	99.6
Redundancy	4.4

Crystallization Conditions

crystal ID	method	pH	temperature	details
1		6.5		PEG 400 44%, MES 50MM PH 6.5