6R28

Structure of peptide P7, which binds Cdc42 and inhibits effector interactions.

Summary for 6R28

• Entry DOI: 10.2210/pdb6r28/pdb
• NMR Information: BMRB: 34380
• Descriptor: peptide P7 (1 entity in total)
• Functional Keywords: inhibitor, cyclic peptide, synthetic peptide., de novo protein
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 2070.40

Authors

Murphy, N.P.,Mott, H.R.,Owen, D. (deposition date: 2019-03-15, release date: 2020-01-29, Last modification date: 2024-03-06)

• Primary citation: Tetley, G.J.N.,Murphy, N.P.,Bonetto, S.,Ivanova-Berndt, G.,Revell, J.,Mott, H.R.,Cooley, R.N.,Owen, D.; The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling.; J.Biol.Chem., 295:2866-2884, 2020; PubMed: 31959628; DOI: 10.1074/jbc.RA119.010077

Experimental method

SOLUTION NMR