2OBF

Structure of K57A hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy (SAH)

Summary for 2OBF

• Entry DOI: 10.2210/pdb2obf/pdb
• Related: 1HNN 2G8N
• Descriptor: Phenylethanolamine N-methyltransferase, (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: methyltransferase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65050.22

Authors

Drinkwater, N.,Martin, J.L. (deposition date: 2006-12-19, release date: 2007-10-09, Last modification date: 2023-10-25)

• Primary citation: Gee, C.L.,Drinkwater, N.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L.; Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase; J.Med.Chem., 50:4845-4853, 2007; PubMed: 17845018; DOI: 10.1021/jm0703385

Experimental method

X-RAY DIFFRACTION (2.3 Å)