3O78
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![BU of 3o78 by Molmil](/molmil-images/mine/3o78) | The structure of Ca2+ Sensor (Case-12) | Descriptor: | CALCIUM ION, Myosin light chain kinase, smooth muscle,Green fluorescent protein,Green fluorescent protein,Calmodulin-1 | Authors: | Leder, L, Stark, W, Freuler, F, Marsh, M, Meyerhofer, M, Stettler, T, Mayr, L.M, Britanova, O.V, Strukova, L.A, Chudakov, D.M. | Deposit date: | 2010-07-30 | Release date: | 2010-09-29 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations Sensors (Basel), 10, 2010
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1MF8
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8BV5
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![BU of 8bv5 by Molmil](/molmil-images/mine/8bv5) | Focus refinement of soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc conditions | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... | Authors: | Khanppnavar, B, Korkhov, V.M. | Deposit date: | 2023-01-04 | Release date: | 2024-01-17 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
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6W4O
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![BU of 6w4o by Molmil](/molmil-images/mine/6w4o) | CaMKII alpha-30 Cryo-EM reconstruction | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Authors: | Chao, L.H, Stratton, M.M. | Deposit date: | 2020-03-11 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation. Sci.Signal., 13, 2020
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8BFM
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![BU of 8bfm by Molmil](/molmil-images/mine/8bfm) | Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ331 | Descriptor: | Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION, pyrazolo[5,1-a]phthalazin-6-amine | Authors: | Kraemer, A, Zhu, W.F, Hernandez-Olmos, V, Proschak, E, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2022-10-26 | Release date: | 2022-11-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2) To Be Published
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6W4P
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![BU of 6w4p by Molmil](/molmil-images/mine/6w4p) | CaMKII alpha-30 Cryo-EM reconstruction - Class B | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Authors: | Chao, L.H, Stratton, M.M. | Deposit date: | 2020-03-11 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation. Sci.Signal., 13, 2020
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7REC
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![BU of 7rec by Molmil](/molmil-images/mine/7rec) | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC | Descriptor: | 5-hydroxydiclofenac, Calcium/calmodulin-dependent protein kinase type II subunit alpha, SODIUM ION | Authors: | McSpadden, E.D, Chi, C.C, Gee, C.L, Kuriyan, J. | Deposit date: | 2021-07-12 | Release date: | 2021-07-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain. Proc.Natl.Acad.Sci.USA, 118, 2021
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5U6Y
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![BU of 5u6y by Molmil](/molmil-images/mine/5u6y) | Pseudo-atomic model of the CaMKIIa holoenzyme. | Descriptor: | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Authors: | Myers, J, Reichow, S.L. | Deposit date: | 2016-12-09 | Release date: | 2017-06-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | The CaMKII holoenzyme structure in activation-competent conformations. Nat Commun, 8, 2017
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4ZLK
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![BU of 4zlk by Molmil](/molmil-images/mine/4zlk) | Crystal structure of mouse myosin-5a in complex with calcium-bound calmodulin | Descriptor: | CALCIUM ION, Calmodulin, Unconventional myosin-Va | Authors: | Shen, M, Zhang, N, Zheng, S, Zhang, W.-B, Zhang, H.-M, Lu, Z, Su, Q.P, Sun, Y, Ye, K, Li, X.-D. | Deposit date: | 2015-05-01 | Release date: | 2016-05-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Structural basis for calcium regulation of myosin 5 motor function To Be Published
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5YVB
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![BU of 5yvb by Molmil](/molmil-images/mine/5yvb) | Structure of CaMKK2 in complex with CKI-011 | Descriptor: | (3Z)-5-chloro-3-[(1-methyl-1H-pyrazol-4-yl)methylidene]-1,3-dihydro-2H-indol-2-one, CHLORIDE ION, Calcium/calmodulin-dependent protein kinase kinase 2, ... | Authors: | Niwa, H, Handa, N, Yokoyama, S. | Deposit date: | 2017-11-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method. J.Mol.Graph.Model., 99, 2020
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5YV9
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![BU of 5yv9 by Molmil](/molmil-images/mine/5yv9) | Structure of CaMKK2 in complex with CKI-009 | Descriptor: | 5-chloro-2-methoxy-4[(1Z)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]aminobenzoic acid, CHLORIDE ION, Calcium/calmodulin-dependent protein kinase kinase 2, ... | Authors: | Niwa, H, Handa, N, Yokoyama, S. | Deposit date: | 2017-11-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method. J.Mol.Graph.Model., 99, 2020
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5YV8
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![BU of 5yv8 by Molmil](/molmil-images/mine/5yv8) | Structure of CaMKK2 in complex with CKI-002 | Descriptor: | 1-amino-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, CHLORIDE ION, Calcium/calmodulin-dependent protein kinase kinase 2, ... | Authors: | Niwa, H, Handa, N, Yokoyama, S. | Deposit date: | 2017-11-24 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.927 Å) | Cite: | Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method. J.Mol.Graph.Model., 99, 2020
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7PQE
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7PPO
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![BU of 7ppo by Molmil](/molmil-images/mine/7ppo) | |
8BUZ
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![BU of 8buz by Molmil](/molmil-images/mine/8buz) | Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Adenylate cyclase type 8, FORSKOLIN, ... | Authors: | Khanppnavar, B, Korkhov, V.M, Mehta, V. | Deposit date: | 2022-12-01 | Release date: | 2023-12-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. Embo Rep., 25, 2024
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2BKI
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![BU of 2bki by Molmil](/molmil-images/mine/2bki) | Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure | Descriptor: | CALCIUM ION, CALMODULIN, SULFATE ION, ... | Authors: | Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. | Deposit date: | 2005-02-16 | Release date: | 2005-06-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal Nature, 435, 2005
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2BDW
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2Y0A
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![BU of 2y0a by Molmil](/molmil-images/mine/2y0a) | Structure of DAPK1 construct residues 1-304 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DEATH-ASSOCIATED PROTEIN KINASE 1 | Authors: | Yumerefendi, H, Mas, P.J, Dordevic, N, McCarthy, A.A, Hart, D.J. | Deposit date: | 2010-12-01 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Library-Based Construct Screening of Death-Associated Protein Kinase 1 Identifies the Minimal Calmodulin Interaction Region and Autoinhibitory Conformation of the Catalytic Domain To be Published
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5COC
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![BU of 5coc by Molmil](/molmil-images/mine/5coc) | Fusion protein of human calmodulin and B4 domain of protein A from staphylococcal aureus | Descriptor: | CALCIUM ION, Immunoglobulin G-binding protein A,Calmodulin | Authors: | Jeong, W.H, Lee, H, Song, D.H, Lee, J.O. | Deposit date: | 2015-07-20 | Release date: | 2016-03-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6691 Å) | Cite: | Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker. Nat Commun, 7, 2016
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6Y4K
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6Y6B
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![BU of 6y6b by Molmil](/molmil-images/mine/6y6b) | Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and 16-OMe-Fusicoccin H | Descriptor: | (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[[(1~{S},3~{R},6~{S},7~{S},8~{R},9~{R},10~{R},11~{R},14~{S})-14-(me thoxymethyl)-3,10-dimethyl-9-oxidanyl-6-propan-2-yl-8-tricyclo[9.3.0.0^{3,7}]tetradecanyl]oxy]oxane-3,4,5-triol, 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2 | Authors: | Lentini Santo, D, Obsilova, V, Obsil, T. | Deposit date: | 2020-02-26 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
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3OXQ
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![BU of 3oxq by Molmil](/molmil-images/mine/3oxq) | Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex | Descriptor: | CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel subunit alpha-1C | Authors: | Kim, E.Y, Rumpf, C.H, Van Petegem, F, Arant, R, Findeisen, F, Cooley, E.S, Isacoff, E.Y, Minor, D.L. | Deposit date: | 2010-09-21 | Release date: | 2010-11-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. Embo J., 29, 2010
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7UA3
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7U9T
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7UA4
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![BU of 7ua4 by Molmil](/molmil-images/mine/7ua4) | |