6Y6B

Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and 16-OMe-Fusicoccin H

Summary for 6Y6B

Entry DOI	10.2210/pdb6y6b/pdb
Descriptor	14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[[(1~{S},3~{R},6~{S},7~{S},8~{R},9~{R},10~{R},11~{R},14~{S})-14-(me thoxymethyl)-3,10-dimethyl-9-oxidanyl-6-propan-2-yl-8-tricyclo[9.3.0.0^{3,7}]tetradecanyl]oxy]oxane-3,4,5-triol (3 entities in total)
Functional Keywords	14-3-3 protein, complex, camkk, fusicoccin, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	57124.31
Authors	Lentini Santo, D.,Obsilova, V.,Obsil, T. (deposition date: 2020-02-26, release date: 2021-02-03, Last modification date: 2024-01-24)
Primary citation	Lentini Santo, D.,Petrvalska, O.,Obsilova, V.,Ottmann, C.,Obsil, T. Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15:3060-3071, 2020 Cited by PubMed: 33146997 DOI: 10.1021/acschembio.0c00821 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.08 Å)

Structure validation