5YV9

Structure of CaMKK2 in complex with CKI-009

Summary for 5YV9

Entry DOI	10.2210/pdb5yv9/pdb
Descriptor	Calcium/calmodulin-dependent protein kinase kinase 2, 5-chloro-2-methoxy-4[(1Z)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]aminobenzoic acid, GLYCEROL, ... (5 entities in total)
Functional Keywords	atp-binding, kinase, serine/threonine-protein kinase, transferase, protein-inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34293.05
Authors	Niwa, H.,Handa, N.,Yokoyama, S. (deposition date: 2017-11-24, release date: 2018-12-05, Last modification date: 2023-11-22)
Primary citation	Takaya, D.,Niwa, H.,Mikuni, J.,Nakamura, K.,Handa, N.,Tanaka, A.,Yokoyama, S.,Honma, T. Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method. J.Mol.Graph.Model., 99:107599-107599, 2020 Cited by PubMed: 32348940 DOI: 10.1016/j.jmgm.2020.107599 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.53 Å)

Structure validation