6UKX
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 11 | Descriptor: | 4,4'-{propane-1,3-diylbis[oxy(5-methoxy-1-benzothiene-6,2-diyl)]}bis(4-oxobutanoic acid), fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | Authors: | Lesburg, C.A. | Deposit date: | 2019-10-06 | Release date: | 2020-08-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UKZ
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 6 | Descriptor: | 4-[5-(2-{[2-(3-carboxypropanoyl)-4-fluoro-6-methoxy-1-benzothiophen-5-yl]oxy}ethoxy)-6-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | Authors: | Lesburg, C.A. | Deposit date: | 2019-10-06 | Release date: | 2020-08-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UKW
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 10 | Descriptor: | 4-[6-(3-{[2-(3-carboxypropanoyl)-4-fluoro-6-methoxy-1-benzothiophen-5-yl]oxy}propoxy)-5-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | Authors: | Lesburg, C.A. | Deposit date: | 2019-10-06 | Release date: | 2020-08-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UKY
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 12 | Descriptor: | 4-(6-{3-[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-4-yl]propyl}-5-methoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | Authors: | Lesburg, C.A. | Deposit date: | 2019-10-06 | Release date: | 2020-08-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UD0
| Solution-state NMR structural ensemble of human Tsg101 UEV in complex with K63-linked diubiquitin | Descriptor: | Tumor susceptibility gene 101 protein, Ubiquitin | Authors: | Strickland, M, Watanabe, S, Bonn, S.M, Camara, C.M, Fushman, D, Carter, C.A, Tjandra, N. | Deposit date: | 2019-09-18 | Release date: | 2021-03-17 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Tsg101/ESCRT-I Recruitment Regulated by the Dual Binding Modes of K63-Linked Diubiquitin Structure, 2021
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6UYJ
| hRpn13:hRpn2:K48-diubiquitin | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | Authors: | Lu, X, Walters, K.J. | Deposit date: | 2019-11-13 | Release date: | 2020-03-11 | Last modified: | 2020-05-20 | Method: | SOLUTION NMR | Cite: | An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure. Structure, 28, 2020
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6VAF
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6UPU
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6UYI
| hRpn13:hRpn2:K48-diubiquitin | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | Authors: | Lu, X, Walters, K.J. | Deposit date: | 2019-11-13 | Release date: | 2020-03-11 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure. Structure, 28, 2020
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6VAE
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6WTG
| SdeA DUB Domain in complex with Ubiquitin | Descriptor: | Ubiquitin, Ubiquitinating/deubiquitinating enzyme SdeA | Authors: | Kenny, S, Sheedlo, M, Das, C. | Deposit date: | 2020-05-02 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA. Biochemistry, 60, 2021
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6XA9
| SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide | Descriptor: | GLYCEROL, ISG15 CTD-propargylamide, Non-structural protein 3, ... | Authors: | Klemm, T, Calleja, D.J, Richardson, L.W, Lechtenberg, B.C, Komander, D. | Deposit date: | 2020-06-04 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. Embo J., 39, 2020
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6XAA
| SARS CoV-2 PLpro in complex with ubiquitin propargylamide | Descriptor: | Non-structural protein 3, Ubiquitin-propargylamide, ZINC ION | Authors: | Klemm, T, Calleja, D.J, Richardson, L.W, Lechtenberg, B.C, Komander, D. | Deposit date: | 2020-06-04 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2. Embo J., 39, 2020
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2WDT
| Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME | Descriptor: | CHLORIDE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3 | Authors: | Weihofen, W.A, Artavanis-Tsakonas, K, Gaudet, R, Ploegh, H.L. | Deposit date: | 2009-03-26 | Release date: | 2009-12-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3. J.Biol.Chem., 285, 2010
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2Y5B
| Structure of USP21 in complex with linear diubiquitin-aldehyde | Descriptor: | SULFATE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21, ... | Authors: | Ye, Y, Akutsu, M, Reyes-Turcu, F, Enchev, R.I, Wilkinson, K.D, Komander, D. | Deposit date: | 2011-01-12 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Polyubiquitin Binding and Cross-Reactivity in the Usp Domain Deubiquitinase Usp21. Embo Rep., 12, 2011
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2XBB
| Nedd4 HECT:Ub complex | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN | Authors: | Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S. | Deposit date: | 2010-04-08 | Release date: | 2011-03-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation Embo Rep., 12, 2011
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2Z59
| Complex Structures of Mouse Rpn13 (22-130aa) and ubiquitin | Descriptor: | Protein ADRM1, Ubiquitin | Authors: | Chen, X, Schreiner, P, Groll, M, Walters, K.J. | Deposit date: | 2007-07-01 | Release date: | 2008-05-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature, 453, 2008
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2ZNV
| Crystal structure of human AMSH-LP DUB domain in complex with Lys63-linked ubiquitin dimer | Descriptor: | 1,2-ETHANEDIOL, AMSH-like protease, Ubiquitin, ... | Authors: | Sato, Y, Azusa, Y, Yamagata, A, Mimura, H, Wang, X, Yamashita, M, Ookata, K, Nureki, O, Iwai, K, Komada, M, Fukai, S. | Deposit date: | 2008-05-01 | Release date: | 2008-09-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Nature, 455, 2008
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2ZVN
| NEMO CoZi domain incomplex with diubiquitin in P212121 space group | Descriptor: | NF-kappa-B essential modulator, UBC protein | Authors: | Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I. | Deposit date: | 2008-11-12 | Release date: | 2009-03-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation Cell(Cambridge,Mass.), 136, 2009
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2ZVO
| NEMO CoZi domain in complex with diubiquitin in C2 space group | Descriptor: | NF-kappa-B essential modulator, UBC protein | Authors: | Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I. | Deposit date: | 2008-11-12 | Release date: | 2009-03-24 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation Cell(Cambridge,Mass.), 136, 2009
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3A1Q
| Crystal structure of the mouse RAP80 UIMs in complex with Lys63-linked di-ubiquitin | Descriptor: | Ubiquitin, Ubiquitin interaction motif-containing protein 1 | Authors: | Sato, Y, Yoshikawa, A, Mimura, H, Yamashita, M, Yamagata, A, Fukai, S. | Deposit date: | 2009-04-21 | Release date: | 2009-07-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80 Embo J., 28, 2009
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3AI5
| Crystal structure of yeast enhanced green fluorescent protein-ubiquitin fusion protein | Descriptor: | 1,2-ETHANEDIOL, yeast enhanced green fluorescent protein,Ubiquitin | Authors: | Suzuki, N, Wakatsuki, S, Kawasaki, M. | Deposit date: | 2010-05-10 | Release date: | 2010-09-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystallization of small proteins assisted by green fluorescent protein Acta Crystallogr.,Sect.D, 66, 2010
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5E6J
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5T35
| The PROTAC MZ1 in complex with the second bromodomain of Brd4 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Transcription elongation factor B polypeptide 1, ... | Authors: | Gadd, M.S, Zengerle, M, Ciulli, A. | Deposit date: | 2016-08-24 | Release date: | 2017-03-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat. Chem. Biol., 13, 2017
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5TL6
| Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15 | Descriptor: | Replicase polyprotein 1ab, SULFATE ION, Ubiquitin-like protein ISG15, ... | Authors: | Dzimianski, J.V, Daczkowski, C.M, Pegan, S.D. | Deposit date: | 2016-10-10 | Release date: | 2017-05-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.618 Å) | Cite: | Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species. J. Mol. Biol., 429, 2017
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