Crystal Structure of Human Otubain2 and Ubiquitin Complex

Summary for 4FJV

DescriptorUbiquitin thioesterase OTUB2, Polyubiquitin-C, GLYCEROL, ... (5 entities in total)
Functional Keywordsubiquitin, otubain, nedd8, cleavage specificity, deubiquitylation, cysteine protease, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationUbiquitin: Cytoplasm  P0CG48
Total number of polymer chains4
Total molecular weight75307.37
Altun, M.,Walter, T.S.,Kramer, H.B.,Iphofer, A.,David, Y.,Komsany, A.,Ternette, N.,Nicholson, B.,Navon, A.,Stuart, D.I.,Ren, J.,Kessler, B.M. (deposition date: 2012-06-12, release date: 2013-06-12, Last modification date: 2015-02-25)
Primary citation
Altun, M.,Walter, T.S.,Kramer, H.B.,Herr, P.,Iphofer, A.,Bostrom, J.,David, Y.,Komsany, A.,Ternette, N.,Navon, A.,Stuart, D.I.,Ren, J.,Kessler, B.M.
The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.
Plos One, 10:e0115344-e0115344, 2015
PubMed: 25590432 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pone.0115344
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.260300.9%0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report