4FJV
Crystal Structure of Human Otubain2 and Ubiquitin Complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0006508 | biological_process | proteolysis |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
A | 0016579 | biological_process | protein deubiquitination |
A | 0016787 | molecular_function | hydrolase activity |
A | 0035871 | biological_process | protein K11-linked deubiquitination |
A | 0043130 | molecular_function | ubiquitin binding |
A | 0070536 | biological_process | protein K63-linked deubiquitination |
A | 0071108 | biological_process | protein K48-linked deubiquitination |
A | 2000780 | biological_process | negative regulation of double-strand break repair |
C | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0006508 | biological_process | proteolysis |
C | 0008234 | molecular_function | cysteine-type peptidase activity |
C | 0016579 | biological_process | protein deubiquitination |
C | 0016787 | molecular_function | hydrolase activity |
C | 0035871 | biological_process | protein K11-linked deubiquitination |
C | 0043130 | molecular_function | ubiquitin binding |
C | 0070536 | biological_process | protein K63-linked deubiquitination |
C | 0071108 | biological_process | protein K48-linked deubiquitination |
C | 2000780 | biological_process | negative regulation of double-strand break repair |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 301 |
Chain | Residue |
A | PHE6 |
A | ASN7 |
A | SER10 |
A | LYS44 |
A | THR45 |
A | LYS46 |
A | HOH599 |
C | ARG20 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 302 |
Chain | Residue |
A | ASP14 |
C | LYS12 |
C | ASP14 |
A | LYS12 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 303 |
Chain | Residue |
A | VAL196 |
A | TYR220 |
A | LYS221 |
A | SER223 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NEH B 101 |
Chain | Residue |
A | GLY49 |
A | CYS51 |
A | SER223 |
B | GLY75 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL C 301 |
Chain | Residue |
A | ARG20 |
C | PHE6 |
C | ASN7 |
C | SER10 |
C | THR45 |
C | GOL303 |
C | HOH481 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL C 302 |
Chain | Residue |
A | SER10 |
A | GLU11 |
A | HOH581 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL C 303 |
Chain | Residue |
A | HOH581 |
C | SER10 |
C | GOL301 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NEH D 101 |
Chain | Residue |
C | GLY49 |
C | CYS51 |
C | SER223 |
C | HIS224 |
D | GLY75 |
Functional Information from PROSITE/UniProt
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
B | ARG54 | |
B | ARG72 | |
D | ARG54 | |
D | ARG72 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | SITE: Essential for function |
Chain | Residue | Details |
B | HIS68 | |
D | HIS68 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
Chain | Residue | Details |
B | SER65 | |
D | SER65 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
Chain | Residue | Details |
B | THR66 | |
D | THR66 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
Chain | Residue | Details |
B | GLY76 | |
D | GLY76 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
B | LYS6 | |
D | LYS6 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
B | GLY76 | |
D | GLY76 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
B | LYS11 | |
B | LYS48 | |
D | LYS11 | |
D | LYS48 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
B | LYS27 | |
D | LYS27 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
Chain | Residue | Details |
B | LYS29 | |
D | LYS29 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
B | LYS33 | |
D | LYS33 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
Chain | Residue | Details |
B | LYS63 | |
D | LYS63 |