PDB: 682 resultsInfo pagesStatus searchChemie searchBIRD

---

7JY5	Structure of human p97 in complex with ATPgammaS and Npl4/Ufd1 (masked around p97) Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Pan, M, Yu, Y, Liu, L, Zhao, M. Deposit date: 2020-08-28 Release date: 2021-01-20 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun, 12, 2021
7JPO	ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-02 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7JPS	ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7KSM	Human mitochondrial LONP1 with endogenous substrate Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... Authors: Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. Deposit date: 2020-11-23 Release date: 2020-12-02 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
7KRZ	Human mitochondrial LONP1 in complex with Bortezomib Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ... Authors: Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. Deposit date: 2020-11-20 Release date: 2021-02-24 Last modified: 2022-06-15 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
7JPR	ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... Authors: Jaremko, M.J, Joshua-Tor, L. Deposit date: 2020-08-09 Release date: 2020-09-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7L5X	p97-R155H mutant dodecamer II Descriptor: Transitional endoplasmic reticulum ATPase Authors: Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. Deposit date: 2020-12-23 Release date: 2021-08-04 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (6.1 Å) Cite: Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int J Mol Sci, 22, 2021
7L6N	The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with three locally refined ClpB middle domains and three DnaK nucleotide binding domains Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, Chaperone protein DnaK, ... Authors: Yin, Y.Y, Feng, X, Li, H. Deposit date: 2020-12-23 Release date: 2021-05-26 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (7 Å) Cite: Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021
7L5W	p97-R155H mutant dodecamer I Descriptor: Transitional endoplasmic reticulum ATPase Authors: Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. Deposit date: 2020-12-23 Release date: 2021-08-04 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.34 Å) Cite: Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int J Mol Sci, 22, 2021
7L9P	Structure of human SHLD2-SHLD3-REV7-TRIP13(E253Q) complex Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pachytene checkpoint protein 2 homolog, ... Authors: Xie, W, Patel, D.J. Deposit date: 2021-01-04 Release date: 2021-03-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex. Proc.Natl.Acad.Sci.USA, 118, 2021
7L9X	Structure of VPS4B in complex with an allele-specific covalent inhibitor Descriptor: N-{3-[(8-phenyl[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino]phenyl}propanamide, SULFATE ION, Vacuolar protein sorting-associated protein 4B Authors: Grasso, M, Cupido, T, Kapoor, T.M. Deposit date: 2021-01-05 Release date: 2021-04-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.81 Å) Cite: A chemical genetics approach to examine the functions of AAA proteins. Nat.Struct.Mol.Biol., 28, 2021
7LJF	Cryo-EM structure of the Mpa hexamer in the presence of ATP and the Pup-FabD substrate Descriptor: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Yin, Y, Li, H. Deposit date: 2021-01-29 Release date: 2021-05-05 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: Cryo-EM structure of the Mpa hexamer in the presence of ATP and the Pup-FabD substrate J.Biol.Chem., 2021
6UKO	Structure analysis of full-length mouse bcs1 complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitochondrial chaperone BCS1 Authors: Xia, D, Esser, L. Deposit date: 2019-10-05 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (4.4 Å) Cite: Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. Nat.Struct.Mol.Biol., 27, 2020
6UGD	Katanin hexamer in the spiral conformation in complex with substrate Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Meiotic spindle formation protein mei-1, ... Authors: Zehr, E.A, Roll-Mecak, A. Deposit date: 2019-09-26 Release date: 2019-10-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Katanin Grips the beta-Tubulin Tail through an Electropositive Double Spiral to Sever Microtubules. Dev.Cell, 52, 2020
6UGE	Katanin hexamer in the ring conformation in complex with substrate Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Meiotic spindle formation protein mei-1, ... Authors: Zehr, E.A, Roll-Mecak, A. Deposit date: 2019-09-26 Release date: 2019-10-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Katanin Grips the beta-Tubulin Tail through an Electropositive Double Spiral to Sever Microtubules. Dev.Cell, 52, 2020
7MHB	Crystal structure of ATP-dependent protease ATPase subunit HslU in complex with Adenosine 5'-diphosphate Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-04-15 Release date: 2021-04-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of ATP-dependent protease ATPase subunit HslU in complex with Adenosine 5'-diphosphate to be published
7MCA	Structure of the S. cerevisiae origin recognition complex bound to the replication initiator Cdc6 and the ARS1 origin DNA. Descriptor: Cell division control protein 6, DNA (85-MER), MAGNESIUM ION, ... Authors: Feng, X, Li, H. Deposit date: 2021-04-01 Release date: 2021-06-02 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nat Commun, 12, 2021
6UKS	ATPgammaS bound mBcs1 Descriptor: MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER Authors: Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. Deposit date: 2019-10-05 Release date: 2020-02-05 Last modified: 2020-02-26 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. Nat.Struct.Mol.Biol., 27, 2020
6U5Z	Cryo-EM structure of E. coli LonA S679A Descriptor: Lon protease Authors: Botos, I, Lountos, G.T, Weimin, W, Wlodawer, A. Deposit date: 2019-08-28 Release date: 2020-02-26 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery Curr Res Struct Biol, 1, 2020
7MDO	Structure of human p97 ATPase L464P mutant Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase Authors: Zhang, X, Gui, L, Li, S, Nandi, P, Columbres, R.C, Wong, D.E, Moen, D.R, Lin, H.J, Chiu, P.-L, Chou, T.-F. Deposit date: 2021-04-05 Release date: 2021-08-25 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (4.12 Å) Cite: Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity. Biochem.J., 478, 2021
7MDM	Structure of human p97 ATPase L464P mutant Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase Authors: Zhang, X, Gui, L, Li, S, Nandi, P, Columbres, R.C, Wong, D.E, Moen, D.R, Lin, H.J, Chiu, P.-L, Chou, T.-F. Deposit date: 2021-04-05 Release date: 2021-08-25 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (4.86 Å) Cite: Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity. Biochem.J., 478, 2021
6UKP	Apo mBcs1 Descriptor: Mitochondrial chaperone BCS1 Authors: Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. Deposit date: 2019-10-05 Release date: 2020-02-12 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. Nat.Struct.Mol.Biol., 27, 2020
6UQE	ClpA/ClpP Disengaged State bound to RepA-GFP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ATP-dependent Clp protease proteolytic subunit, ... Authors: Lopez, K.L, Rizo, A.R, Southworth, D.R. Deposit date: 2019-10-18 Release date: 2020-04-22 Last modified: 2022-03-16 Method: ELECTRON MICROSCOPY (3 Å) Cite: Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat.Struct.Mol.Biol., 27, 2020
6V11	Lon Protease from Yersinia pestis Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease Authors: Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. Deposit date: 2019-11-19 Release date: 2020-01-22 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
7MHS	Structure of p97 (subunits A to E) with substrate engaged Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... Authors: Xu, Y, Han, H, Cooney, I, Hill, C.P, Shen, P.S. Deposit date: 2021-04-15 Release date: 2022-05-11 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Active conformation of the p97-p47 unfoldase complex. Nat Commun, 13, 2022

<9101112131415161718192021222324>