7L9X

Structure of VPS4B in complex with an allele-specific covalent inhibitor

Summary for 7L9X

• Entry DOI: 10.2210/pdb7l9x/pdb
• Descriptor: Vacuolar protein sorting-associated protein 4B, N-{3-[(8-phenyl[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino]phenyl}propanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: chemical inhibitor, hydrolase, atpase, aaa superfamily, protein transport
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 50039.73

Authors

Grasso, M.,Cupido, T.,Kapoor, T.M. (deposition date: 2021-01-05, release date: 2021-04-14, Last modification date: 2023-10-18)

• Primary citation: Cupido, T.,Jones, N.H.,Grasso, M.J.,Pisa, R.,Kapoor, T.M.; A chemical genetics approach to examine the functions of AAA proteins.; Nat.Struct.Mol.Biol., 28:388-397, 2021; PubMed: 33782614; DOI: 10.1038/s41594-021-00575-9

Experimental method

X-RAY DIFFRACTION (2.81 Å)