7L9X

Structure of VPS4B in complex with an allele-specific covalent inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0001778	biological_process	plasma membrane repair
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006914	biological_process	autophagy
A	0006997	biological_process	nucleus organization
A	0007033	biological_process	vacuole organization
A	0007041	biological_process	lysosomal transport
A	0007080	biological_process	mitotic metaphase chromosome alignment
A	0010008	cellular_component	endosome membrane
A	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
A	0010824	biological_process	regulation of centrosome duplication
A	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
A	0016197	biological_process	endosomal transport
A	0016236	biological_process	macroautophagy
A	0016887	molecular_function	ATP hydrolysis activity
A	0030496	cellular_component	midbody
A	0031468	biological_process	nuclear membrane reassembly
A	0031902	cellular_component	late endosome membrane
A	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
A	0033993	biological_process	response to lipid
A	0036258	biological_process	multivesicular body assembly
A	0039702	biological_process	viral budding via host ESCRT complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043162	biological_process	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
A	0044877	molecular_function	protein-containing complex binding
A	0046761	biological_process	viral budding from plasma membrane
A	0051261	biological_process	protein depolymerization
A	0061738	biological_process	late endosomal microautophagy
A	0061764	biological_process	late endosome to lysosome transport via multivesicular body sorting pathway
A	0061952	biological_process	midbody abscission
A	0070062	cellular_component	extracellular exosome
A	0071985	biological_process	multivesicular body sorting pathway
A	0090148	biological_process	membrane fission
A	0090543	cellular_component	Flemming body
A	0090611	biological_process	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
A	0097352	biological_process	autophagosome maturation
A	1901673	biological_process	regulation of mitotic spindle assembly
A	1903542	biological_process	negative regulation of exosomal secretion
A	1903543	biological_process	positive regulation of exosomal secretion
A	1903724	biological_process	positive regulation of centriole elongation
A	1904903	biological_process	ESCRT III complex disassembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue XQV A 501

Chain	Residue
A	CYS135
A	GLY338
A	ALA339
A	SO4502
A	ALA137
A	GLY177
A	THR178
A	GLY179
A	TYR182
A	MET309
A	LEU312
A	HIS313

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site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 502

Chain	Residue
A	GLY177
A	THR178
A	GLY179
A	LYS180
A	SER181
A	XQV501
A	HOH605

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Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	20
Details	AAA AAA-protein family signature. IlVLgATNipwvLDsAIrrR

Chain	Residue	Details
A	ILE272-ARG291

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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