7L9X
Structure of VPS4B in complex with an allele-specific covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vacuolar protein sorting-associated protein 4B | polymer | 446 | 49586.3 | 1 | UniProt (O75351) Pfam (PF04212) Pfam (PF00004) Pfam (PF17862) Pfam (PF09336) In PDB | Homo sapiens (Human) | Cell migration-inducing gene 1 protein,Suppressor of K(+) transport growth defect 1,Protein SKD1 |
| 2 | A | N-{3-[(8-phenyl[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino]phenyl}propanamide | non-polymer | 357.4 | 1 | Chemie (XQV) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 1 - 444 (UniProt: O75351)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Cys 135 | Asp 135 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 49586.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 453.5 | |
| All* | Total formula weight | 50039.7 |
