1F6F
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![BU of 1f6f by Molmil](/molmil-images/mine/1f6f) | CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR | Descriptor: | PLACENTAL LACTOGEN, PROLACTIN RECEPTOR | Authors: | Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A. | Deposit date: | 2000-06-21 | Release date: | 2000-07-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat.Struct.Biol., 7, 2000
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6M77
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![BU of 6m77 by Molmil](/molmil-images/mine/6m77) | |
4BKA
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![BU of 4bka by Molmil](/molmil-images/mine/4bka) | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 | Descriptor: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-23 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (5.3 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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4BK4
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![BU of 4bk4 by Molmil](/molmil-images/mine/4bk4) | crystal structure of the human EphA4 ectodomain | Descriptor: | EPHRIN TYPE-A RECEPTOR 4 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-22 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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6M76
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![BU of 6m76 by Molmil](/molmil-images/mine/6m76) | GH31 alpha-N-acetylgalactosaminidase from Enterococcus faecalis | Descriptor: | 1,2-ETHANEDIOL, LPXTG-motif cell wall anchor domain protein | Authors: | Miyazaki, T. | Deposit date: | 2020-03-17 | Release date: | 2020-05-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of the Enterococcus faecalis alpha-N-acetylgalactosaminidase, a member of the glycoside hydrolase family 31. Febs Lett., 594, 2020
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6MOJ
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![BU of 6moj by Molmil](/molmil-images/mine/6moj) | Dimeric DARPin A_angle_R5 complex with EpoR | Descriptor: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.431 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOK
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![BU of 6mok by Molmil](/molmil-images/mine/6mok) | Dimeric DARPin A_distance_R7 complex with EpoR | Descriptor: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (5.101 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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4BQ7
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![BU of 4bq7 by Molmil](/molmil-images/mine/4bq7) | Crystal structure of the RGMB-Neo1 complex form 2 | Descriptor: | NEOGENIN, RGM DOMAIN FAMILY MEMBER B | Authors: | Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2013-05-30 | Release date: | 2013-06-12 | Last modified: | 2019-04-03 | Method: | X-RAY DIFFRACTION (6.601 Å) | Cite: | Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
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4BQ8
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![BU of 4bq8 by Molmil](/molmil-images/mine/4bq8) | Crystal structure of the RGMB-NEO1 complex form 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NEOGENIN, RGM DOMAIN FAMILY MEMBER B | Authors: | Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2013-05-30 | Release date: | 2013-06-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
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6MOH
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![BU of 6moh by Molmil](/molmil-images/mine/6moh) | Dimeric DARPin C_R3 complex with EpoR | Descriptor: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOI
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![BU of 6moi by Molmil](/molmil-images/mine/6moi) | Dimeric DARPin C_angle_R5 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.065 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOE
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![BU of 6moe by Molmil](/molmil-images/mine/6moe) | Monomeric DARPin E2 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOL
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![BU of 6mol by Molmil](/molmil-images/mine/6mol) | Monoextended DARPin M_R12 complex with EpoR | Descriptor: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.163 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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7Z0L
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![BU of 7z0l by Molmil](/molmil-images/mine/7z0l) | IL-27 signalling complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | Authors: | Jin, Y, Gardner, S, Bubeck, D. | Deposit date: | 2022-02-23 | Release date: | 2022-07-27 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights into the assembly and activation of the IL-27 signaling complex. Embo Rep., 23, 2022
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7YQ3
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![BU of 7yq3 by Molmil](/molmil-images/mine/7yq3) | human insulin receptor bound with A43 DNA aptamer and insulin | Descriptor: | IR-A43 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ4
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![BU of 7yq4 by Molmil](/molmil-images/mine/7yq4) | human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ6
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![BU of 7yq6 by Molmil](/molmil-images/mine/7yq6) | human insulin receptor bound with A62 DNA aptamer | Descriptor: | IR-A62 aptamer, Isoform Short of Insulin receptor | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ5
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![BU of 7yq5 by Molmil](/molmil-images/mine/7yq5) | human insulin receptor bound with A62 DNA aptamer and insulin | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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6MOF
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![BU of 6mof by Molmil](/molmil-images/mine/6mof) | Monomeric DARPin G2 complex with EpoR | Descriptor: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.894 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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4BQ6
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![BU of 4bq6 by Molmil](/molmil-images/mine/4bq6) | Crystal structure of the RGMB-NEO1 complex form 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NEOGENIN, RGM DOMAIN FAMILY MEMBER B | Authors: | Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2013-05-30 | Release date: | 2013-06-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
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5C6P
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![BU of 5c6p by Molmil](/molmil-images/mine/5c6p) | protein C | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, protein C, protein D | Authors: | Lu, M. | Deposit date: | 2015-06-23 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the blockade of MATE multidrug efflux pumps. Nat Commun, 6, 2015
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4BK5
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![BU of 4bk5 by Molmil](/molmil-images/mine/4bk5) | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 (amine-methylated sample) | Descriptor: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-22 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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4BKF
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![BU of 4bkf by Molmil](/molmil-images/mine/4bkf) | crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 | Descriptor: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-B3 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-24 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.65 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
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4MMX
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![BU of 4mmx by Molmil](/molmil-images/mine/4mmx) | Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | Authors: | van Agthoven, J, Xiong, J, Arnaout, M.A. | Deposit date: | 2013-09-09 | Release date: | 2014-03-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
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4OV6
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![BU of 4ov6 by Molmil](/molmil-images/mine/4ov6) | Crystal structure of PCSK9(53-451) with Adnectin | Descriptor: | 1,2-ETHANEDIOL, Adnectin, Proprotein convertase subtilisin/kexin type 9, ... | Authors: | Khan, J.A. | Deposit date: | 2014-02-20 | Release date: | 2014-07-02 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering. J.Pharmacol.Exp.Ther., 350, 2014
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