3H9R
 
 | | Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin | | Descriptor: | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Activin receptor type-1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Chaikuad, A, Alfano, I, Shrestha, B, Muniz, J.R.C, Petrie, K, Fedorov, O, Phillips, C, Bishop, S, Mahajan, P, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-04-30 | | Release date: | 2009-06-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva.
J.Biol.Chem., 287, 2012
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2VCD
 | | Solution structure of the FKBP-domain of Legionella pneumophila Mip in complex with rapamycin | | Descriptor: | Outer membrane protein MIP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | Authors: | Ceymann, A, Horstmann, M, Ehses, P, Schweimer, K, Paschke, A.-K, Fischer, G, Roesch, P, Faber, C. | | Deposit date: | 2007-09-20 | | Release date: | 2008-09-02 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Legionella pneumophila Mip-rapamycin complex.
BMC Struct. Biol., 8, 2008
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3J8H
 | | Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution | | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | | Authors: | Yan, Z, Bai, X, Yan, C, Wu, J, Scheres, S.H.W, Shi, Y, Yan, N. | | Deposit date: | 2014-10-26 | | Release date: | 2014-12-10 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.
Nature, 517, 2015
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2UZ5
 | | Solution structure of the fkbp-domain of Legionella pneumophila Mip | | Descriptor: | MACROPHAGE INFECTIVITY POTENTIATOR | | Authors: | Ceymann, A, Horstmann, M, Ehses, P, Schweimer, K, Steinert, M, Kamphausen, T, Fischer, G, Hacker, J, Rosch, P, Faber, C. | | Deposit date: | 2007-04-25 | | Release date: | 2007-06-12 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Domain Motions of the Mip Protein from Legionella Pneumophila
Biochemistry, 45, 2006
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2RSE
 | | NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS | | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, TERBIUM(III) ION | | Authors: | Kobashigawa, Y, Ushio, M, Saio, T, Inagaki, F. | | Deposit date: | 2012-01-25 | | Release date: | 2012-05-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Convenient method for resolving degeneracies due to symmetry of the magnetic susceptibility tensor and its application to pseudo contact shift-based protein-protein complex structure determination.
J.Biomol.Nmr, 53, 2012
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2VRH
 | | Structure of the E. coli trigger factor bound to a translating ribosome | | Descriptor: | 50S RIBOSOMAL PROTEIN L23, 50S RIBOSOMAL PROTEIN L24, 50S RIBOSOMAL PROTEIN L29, ... | | Authors: | Merz, F, Boehringer, D, Schaffitzel, C, Preissler, S, Hoffmann, A, Maier, T, Rutkowska, A, Lozza, J, Ban, N, Bukau, B, Deuerling, E. | | Deposit date: | 2008-04-07 | | Release date: | 2008-06-17 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (19 Å) | | Cite: | Molecular Mechanism and Structure of Trigger Factor Bound to the Translating Ribosome.
Embo J., 27, 2008
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1W26
 | | Trigger Factor in Complex with the Ribosome forms a Molecular Cradle for Nascent Proteins | | Descriptor: | TRIGGER FACTOR | | Authors: | Ferbitz, L, Maier, T, Patzelt, H, Bukau, B, Deuerling, E, Ban, N. | | Deposit date: | 2004-06-28 | | Release date: | 2004-09-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Trigger Factor in Complex with the Ribosome Forms a Molecular Cradle for Nascent Proteins
Nature, 431, 2004
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1T11
 | | Trigger Factor | | Descriptor: | Trigger factor | | Authors: | Ludlam, A.V, Moore, B.A, Xu, Z. | | Deposit date: | 2004-04-14 | | Release date: | 2004-09-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of ribosomal chaperone trigger factor from Vibrio cholerae.
Proc.Natl.Acad.Sci.USA, 101, 2004
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1FD9
 | | CRYSTAL STRUCTURE OF THE MACROPHAGE INFECTIVITY POTENTIATOR PROTEIN (MIP) A MAJOR VIRULENCE FACTOR FROM LEGIONELLA PNEUMOPHILA | | Descriptor: | PROTEIN (MACROPHAGE INFECTIVITY POTENTIATOR PROTEIN), ZINC ION | | Authors: | Riboldi-Tunnicliffe, A, Jessen, S, Konig, B, Rahfeld, J, Hacker, J, Fischer, G, Hilgenfeld, R. | | Deposit date: | 2000-07-20 | | Release date: | 2001-07-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Crystal structure of Mip, a prolylisomerase from Legionella pneumophila
Nat.Struct.Biol., 8, 2001
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1FAP
 | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | | Descriptor: | FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | Authors: | Choi, J, Chen, J, Schreiber, S.L, Clardy, J. | | Deposit date: | 1996-03-15 | | Release date: | 1997-07-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science, 273, 1996
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1KT1
 | | Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes | | Descriptor: | FK506-binding protein FKBP51, SULFATE ION | | Authors: | Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. | | Deposit date: | 2002-01-14 | | Release date: | 2003-02-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | STRUCTURE OF THE LARGE FK506-BINDING PROTEIN FKBP51, AN HSP90-BINDING PROTEIN AND A COMPONENT OF STEROID RECEPTOR COMPLEXES
Proc.Natl.Acad.Sci.USA, 100, 2003
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1KT0
 | | Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes | | Descriptor: | 51 KDA FK506-BINDING PROTEIN, SULFATE ION | | Authors: | Sinars, C.R, Cheung-Flynn, J, Rimerman, R.A, Scammell, J.G, Smith, D.F, Clardy, J.C. | | Deposit date: | 2002-01-14 | | Release date: | 2003-02-04 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a
component of steroid receptor complexes
Proc.Natl.Acad.Sci.USA, 100, 2003
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7CF9
 | | Structure of RyR1 (Ca2+/CHL) | | Descriptor: | 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | | Authors: | Ma, R, Haji-Ghassemi, O, Ma, D, Lin, L, Samurkas, A, Van Petegem, F, Yuchi, Z. | | Deposit date: | 2020-06-24 | | Release date: | 2020-09-02 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structural basis for diamide modulation of ryanodine receptor.
Nat.Chem.Biol., 16, 2020
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2IF4
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8DUJ
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8DVE
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8DTZ
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8DTY
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8DVV
 | | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions | | Descriptor: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | | Authors: | Iyer, K.A, Hu, Y, Murayama, T, Samso, M. | | Deposit date: | 2022-07-29 | | Release date: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions
To Be Published
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8ERA
 | | RMC-5552 in complex with mTORC1 and FKBP12 | | Descriptor: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Tomlinson, A.C.A, Yano, J.K. | | Deposit date: | 2022-10-11 | | Release date: | 2022-12-28 | | Last modified: | 2023-01-25 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
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8ER6
 | | FKBP12-FRB in Complex with Compound 11 | | Descriptor: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1,2-ETHANEDIOL, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Tomlinson, A.C.A, Yano, J.K. | | Deposit date: | 2022-10-11 | | Release date: | 2022-12-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
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8ER7
 | | FKBP12-FRB in Complex with Compound 12 | | Descriptor: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-5,10,21-trimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Tomlinson, A.C.A, Yano, J.K. | | Deposit date: | 2022-10-11 | | Release date: | 2022-12-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.07 Å) | | Cite: | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
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7DEK
 | | Pseudomonas aeruginosa FK506-binding protein PaFkbA | | Descriptor: | Peptidyl-prolyl cis-trans isomerase | | Authors: | Ynag, J, Huang, Q, Bao, R. | | Deposit date: | 2020-11-04 | | Release date: | 2021-09-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural characterization of PaFkbA: A periplasmic chaperone from Pseudomonas aeruginosa .
Comput Struct Biotechnol J, 19, 2021
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7VMS
 | | Structure of recombinant RyR2 mutant K4593A (Ca2+ dataset) | | Descriptor: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | | Authors: | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | | Deposit date: | 2021-10-09 | | Release date: | 2022-08-10 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
Nat Commun, 13, 2022
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7VML
 | | Structure of recombinant RyR2 (EGTA dataset, class 1&2, closed state) | | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | | Authors: | Kobayashi, T, Tsutsumi, A, Kurebayashi, N, Kodama, M, Kikkawa, M, Murayama, T, Ogawa, H. | | Deposit date: | 2021-10-09 | | Release date: | 2022-08-10 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.
Nat Commun, 13, 2022
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