7T64
Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6 embedded in lipidic nanodisc in the closed state
This is a non-PDB format compatible entry.
Summary for 7T64
Entry DOI | 10.2210/pdb7t64/pdb |
EMDB information | 25709 |
Descriptor | Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION (3 entities in total) |
Functional Keywords | ryanodine receptor, ryr, ryr1, calcium channel, mutation, ntdc mutation, malignant hyperthermia, central core disease, membrane protein, excitation-contraction coupling |
Biological source | Oryctolagus cuniculus (rabbit) More |
Total number of polymer chains | 8 |
Total formula weight | 2310261.10 |
Authors | Iyer, K.A.,Hu, Y.,Murayama, T.,Samso, M. (deposition date: 2021-12-13, release date: 2022-07-20, Last modification date: 2024-02-28) |
Primary citation | Iyer, K.A.,Hu, Y.,Klose, T.,Murayama, T.,Samso, M. Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM. Proc.Natl.Acad.Sci.USA, 119:e2122140119-e2122140119, 2022 Cited by PubMed: 35867837DOI: 10.1073/pnas.2122140119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
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