7T64
Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6 embedded in lipidic nanodisc in the closed state
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Ryanodine receptor 1 | polymer | 5037 | 565832.6 | 4 | UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119) | Oryctolagus cuniculus (rabbit) | RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor |
| 2 | E, F, G, H (E, F, G, H) | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 107 | 11667.3 | 4 | UniProt (P68106) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 3 | I, J, K, L (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
A, B, C, D: 1 - 5037 (UniProt: P11716)
| PDB | External Database | Details |
|---|---|---|
| Ser 523 | Tyr 523 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 2309999.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 2310261.1 |
