7T65

Rabbit RyR1 disease mutant Y523S in complex with FKBP12.6 embedded in lipidic nanodisc in the open state

This is a non-PDB format compatible entry.

Summary for 7T65

• Entry DOI: 10.2210/pdb7t65/pdb
• EMDB information: 25710
• Descriptor: Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1B, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: ryanodine receptor, ryr, ryr1, calcium channel, mutation, ntdc mutation, malignant hyperthermia, central core disease, membrane protein, excitation-contraction coupling
• Biological source: Oryctolagus cuniculus (rabbit); More
• Total number of polymer chains: 8
• Total formula weight: 2312450.14

Authors

Iyer, K.A.,Hu, Y.,Murayama, T.,Samso, M. (deposition date: 2021-12-13, release date: 2022-07-20, Last modification date: 2022-08-03)

• Primary citation: Iyer, K.A.,Hu, Y.,Klose, T.,Murayama, T.,Samso, M.; Molecular mechanism of the severe MH/CCD mutation Y522S in skeletal ryanodine receptor (RyR1) by cryo-EM.; Proc.Natl.Acad.Sci.USA, 119:e2122140119-e2122140119, 2022; PubMed: 35867837; DOI: 10.1073/pnas.2122140119

Experimental method

ELECTRON MICROSCOPY (4.05 Å)