PDB: 221051 resultsInfo pagesStatus searchChemie searchBIRD

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8WWS	Crystal structure of cis-epoxysuccinate hydrolase from Klebsiella oxytoca with L(+)-tartaric acid Descriptor: (S)-2-haloacid dehalogenase, 1,2-ETHANEDIOL, CARBONATE ION, ... Authors: Han, Y, Kong, X.D, Li, J, Xu, J.H. Deposit date: 2023-10-26 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Structural Insights of a cis-Epoxysuccinate Hydrolase Facilitate the Development of Robust Biocatalysts for the Production of l-(+)-Tartrate Biochemistry, 2024
8WZU	4-hydroxybutyryl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus. Descriptor: 4-hydroxybutyrate--CoA ligase [ADP-forming], SULFATE ION Authors: Johnson, J, Demirci, H. Deposit date: 2023-11-02 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of 4-hydroxybutyryl CoA synthetase (ADP-forming): A Key Enzyme in the Thaumarchaeal Hydroxypropionate/Hydroxybutyrate cycle. To Be Published
8X8L	Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex Descriptor: Cortistatin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Xu, H.E, You, C, Zhao, L, Li, J. Deposit date: 2023-11-27 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex To Be Published
8X8N	Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha, ... Authors: Xu, H.E, You, C, Zhao, L, Li, J. Deposit date: 2023-11-27 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex To Be Published
8XFV	Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-(piperidin-4-yloxy)indolin-2-one Descriptor: 3-(1~{H}-benzimidazol-5-ylmethylidene)-4-piperidin-4-yloxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION Authors: Li, G.-B, Wang, X.-Y. Deposit date: 2023-12-14 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (3.13 Å) Cite: X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 2024
8XGA	Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((tetrahydro-2H-pyran-4-yl)oxy)indolin-2-one Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-(oxan-4-yloxy)-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase-like protein, ZINC ION Authors: Li, G.-B, Wang, X.-Y. Deposit date: 2023-12-15 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (3.537 Å) Cite: X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 2024
8XGB	Crystal structure of human secretory glutaminyl cyclase in complex with (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one Descriptor: (5~{S})-1-(3~{H}-benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION Authors: Li, G.-B, Wang, X.-Y. Deposit date: 2023-12-15 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (3.24 Å) Cite: X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 2024
8XGT	Crystal structure of human secretory glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-hydroxyindolin-2-one Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-oxidanyl-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION Authors: Li, G.-B, Wang, X.-Y. Deposit date: 2023-12-15 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.813 Å) Cite: X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 2024
8XGY	Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one Descriptor: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION Authors: Li, G.-B, Wang, X.-Y. Deposit date: 2023-12-16 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.81 Å) Cite: X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 2024
8XS3	Structure of MPXV B6 and D68 fab complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D68_heavy chain, ... Authors: wu, L.L, Sun, J.Q. Deposit date: 2024-01-08 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Two noncompeting human neutralizing antibodies targeting MPXV B6 show potent efficacies against orthopoxvirus infections To Be Published
8XZD	The structure of fox ACE2 and Omicron BF.7 RBD complex Descriptor: Angiotensin-converting enzyme, Spike protein S1, ZINC ION Authors: sun, J.Q. Deposit date: 2024-01-21 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: The structure of fox ACE2 and Omicron BF.7 RBD complex To Be Published
8Y7R	Crystal structure of a novel ketoreductase from Sphingobacterium siyangense SY1 Descriptor: NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family) Authors: Zheng, Z.R, Wei, H.L, Liu, W.D, You, S. Deposit date: 2024-02-05 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Crystal structure of a novel ketoreductase from Sphingobacterium siyangense SY1 To Be Published
8Y83	Crystal structure of a ketoreductase from Sphingobacterium siyangense SY1 with co-enzyme Descriptor: NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family), NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Zheng, Z.R, Wei, H.L, Liu, W.D, You, S. Deposit date: 2024-02-05 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a ketoreductase from Sphingobacterium siyangense SY1 with co-enzyme To Be Published
8YF0	Cryo-EM structure of human SV2A Descriptor: Synaptic vesicle glycoprotein 2A Authors: Qu, Q, Liu, S, Zhou, Z. Deposit date: 2024-02-23 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Cryo-EM structure of human SV2A To Be Published
8YF1	Cryo-EM structure of human SV2A in complex with Brivaracetam Descriptor: (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, Synaptic vesicle glycoprotein 2A Authors: Qu, Q, Liu, S, Zhou, Z. Deposit date: 2024-02-23 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Cryo-EM structure of human SV2A in complex with Brivaracetam To Be Published
8YKI	FGFR-1 in complex with ligand tasurgratinib Descriptor: CHLORIDE ION, Fibroblast growth factor receptor 1, Tasurgratinib Authors: Ikemori-Kawada, M, Watanabe Miyano, S. Deposit date: 2024-03-05 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion. Anticancer Res., 44, 2024
8YLC	The crystal structure of PDE4D with Amentoflavone Descriptor: 3',5'-cyclic-AMP phosphodiesterase 4D, 8-[5-[5,7-bis(oxidanyl)-4-oxidanylidene-chromen-2-yl]-2-oxidanyl-phenyl]-2-(4-hydroxyphenyl)-5,7-bis(oxidanyl)chromen-4-one, MAGNESIUM ION, ... Authors: Huang, Y.-Y, Luo, H.-B. Deposit date: 2024-03-06 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.30003715 Å) Cite: Discovery of amentoflavone as a natural PDE4 inhibitor with anti-fibrotic effects Chin.Chem.Lett., 2024
8ZBO	Crystal structure of the biphotochromic fluorescent protein moxSAASoti (F97M variant) in its green on-state Descriptor: 1,2-ETHANEDIOL, F97M variant of the biphotochromic fluorescent protein moxSAASoti, NITRATE ION, ... Authors: Boyko, K.M, Matyuta, I.O, Marynich, N.K, Minyaev, M.E, Khadiyatova, A.A, Popov, V.O, Savitsky, A.P. Deposit date: 2024-04-26 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and fluorescent study of the in cellulo crystallizable fluorescent protein moxSAASoti F97M To Be Published
8ZKC	iron-sulfur cluster transfer protein ApbC Descriptor: GLYCEROL, Iron-sulfur cluster carrier protein, MAGNESIUM ION Authors: Yang, J, Liu, L. Deposit date: 2024-05-16 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal structure of the iron-sulfur cluster transfer protein ApbC from Escherichia coli. Biochem.Biophys.Res.Commun., 722, 2024
8ZKV	Engineering Threonine Deaminase Catalytic Domain into a Tetrameric Configuration, Independent of Allosteric Regulation Descriptor: L-threonine dehydratase biosynthetic IlvA, SULFATE ION Authors: Khodi, S. Deposit date: 2024-05-17 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Investigating the Dynamics of Catalytic Domains in Threonine Deaminase to Elucidating Allosteric Regulation To Be Published
8ZNB	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH in the steady stage of reaction Descriptor: Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.53 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8ZNC	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH, AKG in the steady stage of reaction Descriptor: 2-OXOGLUTARIC ACID, AMMONIUM ION, Glutamate dehydrogenase, ... Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.41 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8ZND	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus incorporating NADPH and a substrate in the steady stage of reaction Descriptor: Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.53 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8ZNG	Cryo-EM structure of W89F mutated Glutamate dehydrogenase from Thermococcus profundus in complex with NADPH and AKG in the steady stage of reaction Descriptor: 2-OXOGLUTARIC ACID, Glutamate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wakabayashi, T, Nakasako, M. Deposit date: 2024-05-26 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action To Be Published
8ZOZ	Crystal structure of the complex of glyceraldehyde-3-phosphate dehydrogenase of type B from Acinetobacter baumannii with Adenosine monophosphate at 3.20 A resolution. Descriptor: ADENOSINE MONOPHOSPHATE, Glyceraldehyde-3-phosphate dehydrogenase, SULFATE ION Authors: Pahuja, P, Viswanathan, V, Kumari, A, Singh, A, Kumar, A, Sharma, P, Chopra, S, Sharma, S, Raje, C.I, Singh, T.P. Deposit date: 2024-05-29 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the complex of glyceraldehyde-3-phosphate dehydrogenase of type B from Acinetobacter baumannii with Adenosine monophosphate at 3.20 A resolution. To Be Published

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