8XGY

Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one

This is a non-PDB format compatible entry.

Summary for 8XGY

• Entry DOI: 10.2210/pdb8xgy/pdb
• Descriptor: Glutaminyl-peptide cyclotransferase, ZINC ION, (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 456134.71

Authors

Li, G.-B.,Wang, X.-Y. (deposition date: 2023-12-16, release date: 2024-06-12, Last modification date: 2024-06-26)

• Primary citation: Mou, J.,Ning, X.L.,Wang, X.Y.,Hou, S.Y.,Meng, F.B.,Zhou, C.,Wu, J.W.,Li, C.,Jia, T.,Wu, X.,Wu, Y.,Chen, Y.,Li, G.B.; X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.; J.Med.Chem., 67:8730-8756, 2024; PubMed: 38817193; DOI: 10.1021/acs.jmedchem.4c00049

Experimental method

X-RAY DIFFRACTION (2.81 Å)