8XGY

Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0008270	molecular_function	zinc ion binding
A	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
A	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
A	0035580	cellular_component	specific granule lumen
A	0036211	biological_process	protein modification process
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0008270	molecular_function	zinc ion binding
B	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
B	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
B	0035580	cellular_component	specific granule lumen
B	0036211	biological_process	protein modification process
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0008270	molecular_function	zinc ion binding
C	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
C	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
C	0035580	cellular_component	specific granule lumen
C	0036211	biological_process	protein modification process
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0008270	molecular_function	zinc ion binding
D	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
D	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
D	0035580	cellular_component	specific granule lumen
D	0036211	biological_process	protein modification process
D	0070062	cellular_component	extracellular exosome
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0008270	molecular_function	zinc ion binding
E	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
E	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
E	0035580	cellular_component	specific granule lumen
E	0036211	biological_process	protein modification process
E	0070062	cellular_component	extracellular exosome
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0008270	molecular_function	zinc ion binding
F	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
F	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
F	0035580	cellular_component	specific granule lumen
F	0036211	biological_process	protein modification process
F	0070062	cellular_component	extracellular exosome
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0008270	molecular_function	zinc ion binding
G	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
G	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
G	0035580	cellular_component	specific granule lumen
G	0036211	biological_process	protein modification process
G	0070062	cellular_component	extracellular exosome
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0008270	molecular_function	zinc ion binding
H	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
H	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
H	0035580	cellular_component	specific granule lumen
H	0036211	biological_process	protein modification process
H	0070062	cellular_component	extracellular exosome
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0008270	molecular_function	zinc ion binding
I	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
I	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
I	0035580	cellular_component	specific granule lumen
I	0036211	biological_process	protein modification process
I	0070062	cellular_component	extracellular exosome
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0008270	molecular_function	zinc ion binding
J	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
J	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
J	0035580	cellular_component	specific granule lumen
J	0036211	biological_process	protein modification process
J	0070062	cellular_component	extracellular exosome
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0008270	molecular_function	zinc ion binding
K	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
K	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
K	0035580	cellular_component	specific granule lumen
K	0036211	biological_process	protein modification process
K	0070062	cellular_component	extracellular exosome
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0008270	molecular_function	zinc ion binding
L	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
L	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
L	0035580	cellular_component	specific granule lumen
L	0036211	biological_process	protein modification process
L	0070062	cellular_component	extracellular exosome
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"18072935","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16135565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18072935","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21288892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21671571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZEP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SI0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YWY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21671571","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---