1LMJ
| NMR Study of the Fibrillin-1 cbEGF12-13 Pair of Ca2+ Binding Epidermal Growth Factor-like Domains | Descriptor: | CALCIUM ION, fibrillin 1 | Authors: | Smallridge, R.S, Whiteman, P, Werner, J.M, Campbell, I.D, Handford, P.A, Downing, A.K. | Deposit date: | 2002-05-02 | Release date: | 2003-04-29 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution Structure and Dynamics of a Calcium Binding Epidermal Growth
Factor-like Domain Pair from the Neonatal Region of Human Fibrillin-1. J.Biol.Chem., 278, 2003
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2KL7
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2BOX
| EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium. | Descriptor: | CACODYLATE ION, CHLORIDE ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR, ... | Authors: | Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M. | Deposit date: | 2005-04-14 | Release date: | 2006-10-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55. J.Biol.Chem., 282, 2007
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2BO2
| EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium. | Descriptor: | CACODYLATE ION, CALCIUM ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR | Authors: | Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M. | Deposit date: | 2005-04-07 | Release date: | 2006-08-09 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55. J.Biol.Chem., 282, 2007
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1EMN
| NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE | Descriptor: | CALCIUM ION, FIBRILLIN | Authors: | Downing, A.K, Campbell, I.D, Handford, P.A. | Deposit date: | 1996-08-05 | Release date: | 1996-12-23 | Last modified: | 2024-10-09 | Method: | SOLUTION NMR | Cite: | Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Cell(Cambridge,Mass.), 85, 1996
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1EMO
| NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 22 STRUCTURES | Descriptor: | CALCIUM ION, FIBRILLIN | Authors: | Downing, A.K, Campbell, I.D, Handford, P.A. | Deposit date: | 1996-08-05 | Release date: | 1996-12-23 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Cell(Cambridge,Mass.), 85, 1996
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1Z6C
| Solution structure of an EGF pair (EGF34) from vitamin K-dependent protein S | Descriptor: | CALCIUM ION, Vitamin K-dependent protein S | Authors: | Drakenberg, T, Ghasriani, H, Thulin, E, Thamlitz, A.M, Muranyi, A, Annila, A, Stenflo, J. | Deposit date: | 2005-03-22 | Release date: | 2005-06-21 | Last modified: | 2024-10-16 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Ca(2+)-Binding EGF3-4 Pair from Vitamin K-Dependent Protein S: Identification of an Unusual Fold in EGF3. Biochemistry, 44, 2005
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2BOU
| EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium. | Descriptor: | BARIUM ION, CACODYLATE ION, CALCIUM ION, ... | Authors: | Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M. | Deposit date: | 2005-04-14 | Release date: | 2006-10-18 | Last modified: | 2017-01-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55. J.Biol.Chem., 282, 2007
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9ETN
| Crystal structure of murine CRTAC1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Cartilage acidic protein 1, ... | Authors: | Beugelink, J.W, Hof, H, Janssen, B.J.C. | Deposit date: | 2024-03-26 | Release date: | 2024-07-31 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.584 Å) | Cite: | CRTAC1 has a Compact beta-propeller-TTR Core Stabilized by Potassium Ions. J.Mol.Biol., 436, 2024
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6TQK
| Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, ... | Authors: | Stsiapanava, A, Xu, C, Carroni, M, Wu, B, Jovine, L. | Deposit date: | 2019-12-16 | Release date: | 2020-11-04 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cryo-EM structure of native human uromodulin, a zona pellucida module polymer. Embo J., 39, 2020
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7ALJ
| Structure of Drosophila Notch EGF domains 11-13 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus Notch protein, ... | Authors: | Suckling, R, Johnson, S, Lea, S.M. | Deposit date: | 2020-10-06 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling. Embo Rep., 22, 2021
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1NT0
| Crystal structure of the CUB1-EGF-CUB2 region of MASP2 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Feinberg, H, Uitdehaag, J.C.M, Davies, J.M, Wallis, R, Drickamer, K, Weis, W.I. | Deposit date: | 2003-01-28 | Release date: | 2003-05-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2 Embo J., 22, 2003
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7DO4
| Crystal structure of CD97-CD55 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Niu, M, Song, G. | Deposit date: | 2020-12-11 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs. J.Biol.Chem., 296, 2021
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5UK5
| Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Garcia, K.C, Luca, V.C. | Deposit date: | 2017-01-19 | Release date: | 2017-03-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.506 Å) | Cite: | Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science, 355, 2017
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8UFB
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4XL1
| Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Luca, V.C, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-01-13 | Release date: | 2015-03-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science, 347, 2015
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4XLW
| Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Delta-like protein, ... | Authors: | Luca, V.C, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-01-13 | Release date: | 2015-03-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.39 Å) | Cite: | Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science, 347, 2015
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5FM9
| human Notch 1, EGF 4-7 | Descriptor: | CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 | Authors: | Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C. | Deposit date: | 2015-11-02 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24, 2016
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2W86
| Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form | Descriptor: | CALCIUM ION, FIBRILLIN-1, IODIDE ION | Authors: | Jensen, S.A, Iqbal, S, Lowe, E.D, Redfield, C, Handford, P.A. | Deposit date: | 2009-01-09 | Release date: | 2009-05-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/Ltbp Superfamily of Matrix Proteins. Structure, 17, 2009
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5MWB
| Human Notch-2 EGF11-13 | Descriptor: | CALCIUM ION, Neurogenic locus notch homolog protein 2, alpha-L-fucopyranose, ... | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MS9
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7PFP
| Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B. | Deposit date: | 2021-08-11 | Release date: | 2022-03-16 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH. Nat.Struct.Mol.Biol., 29, 2022
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7Q3N
| Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and the FimH lectin domain from uropathogenic E. coli | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Type 1 fimbiral adhesin FimH, ... | Authors: | Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B. | Deposit date: | 2021-10-28 | Release date: | 2022-03-16 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH. Nat.Struct.Mol.Biol., 29, 2022
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6ZS5
| 3.5 A cryo-EM structure of human uromodulin filament core | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R. | Deposit date: | 2020-07-15 | Release date: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. Elife, 9, 2020
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6POL
| Crystal structure of the human NELL1 EGF1-3-Robo3 FN1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Wang, J, Pak, J.S, Ozkan, E. | Deposit date: | 2019-07-04 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance. Nat Commun, 11, 2020
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