6TQK

Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament.

Summary for 6TQK

• Entry DOI: 10.2210/pdb6tqk/pdb
• Related: 3NK4 4WRN 6TQL
• EMDB information: 10553 10554
• Descriptor: Uromodulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: zp module, zp domain, zp-n domain, zp-c domain, interdomain linker, egf domain, extracellular matrix, glycoprotein, n-glycan, structural protein, protein filament, protein polymerization
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 188746.36

Authors

Stsiapanava, A.,Xu, C.,Carroni, M.,Wu, B.,Jovine, L. (deposition date: 2019-12-16, release date: 2020-11-04, Last modification date: 2021-03-03)

• Primary citation: Stsiapanava, A.,Xu, C.,Brunati, M.,Zamora-Caballero, S.,Schaeffer, C.,Bokhove, M.,Han, L.,Hebert, H.,Carroni, M.,Yasumasu, S.,Rampoldi, L.,Wu, B.,Jovine, L.; Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.; Embo J., 39:e106807-e106807, 2020; PubMed: 33196145; DOI: 10.15252/embj.2020106807

Experimental method

ELECTRON MICROSCOPY (3.35 Å)