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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6TQK

Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000922cellular_componentspindle pole
A0002376biological_processimmune system process
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005783cellular_componentendoplasmic reticulum
A0005796cellular_componentGolgi lumen
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006968biological_processcellular defense response
A0007157biological_processheterophilic cell-cell adhesion
A0007159biological_processleukocyte cell-cell adhesion
A0008285biological_processnegative regulation of cell population proliferation
A0009986cellular_componentcell surface
A0010467biological_processgene expression
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0019864molecular_functionIgG binding
A0019898cellular_componentextrinsic component of membrane
A0045087biological_processinnate immune response
A0050801biological_processmonoatomic ion homeostasis
A0050829biological_processdefense response to Gram-negative bacterium
A0060170cellular_componentciliary membrane
A0070062cellular_componentextracellular exosome
A0071692biological_processprotein localization to extracellular region
A0072218biological_processmetanephric ascending thin limb development
A0072221biological_processmetanephric distal convoluted tubule development
A0072233biological_processmetanephric thick ascending limb development
A0098552cellular_componentside of membrane
A0140367biological_processantibacterial innate immune response
A1990266biological_processneutrophil migration
B0000922cellular_componentspindle pole
B0002376biological_processimmune system process
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005783cellular_componentendoplasmic reticulum
B0005796cellular_componentGolgi lumen
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006968biological_processcellular defense response
B0007157biological_processheterophilic cell-cell adhesion
B0007159biological_processleukocyte cell-cell adhesion
B0008285biological_processnegative regulation of cell population proliferation
B0009986cellular_componentcell surface
B0010467biological_processgene expression
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0019864molecular_functionIgG binding
B0019898cellular_componentextrinsic component of membrane
B0045087biological_processinnate immune response
B0050801biological_processmonoatomic ion homeostasis
B0050829biological_processdefense response to Gram-negative bacterium
B0060170cellular_componentciliary membrane
B0070062cellular_componentextracellular exosome
B0071692biological_processprotein localization to extracellular region
B0072218biological_processmetanephric ascending thin limb development
B0072221biological_processmetanephric distal convoluted tubule development
B0072233biological_processmetanephric thick ascending limb development
B0098552cellular_componentside of membrane
B0140367biological_processantibacterial innate immune response
B1990266biological_processneutrophil migration
C0000922cellular_componentspindle pole
C0002376biological_processimmune system process
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005783cellular_componentendoplasmic reticulum
C0005796cellular_componentGolgi lumen
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006968biological_processcellular defense response
C0007157biological_processheterophilic cell-cell adhesion
C0007159biological_processleukocyte cell-cell adhesion
C0008285biological_processnegative regulation of cell population proliferation
C0009986cellular_componentcell surface
C0010467biological_processgene expression
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016324cellular_componentapical plasma membrane
C0019864molecular_functionIgG binding
C0019898cellular_componentextrinsic component of membrane
C0045087biological_processinnate immune response
C0050801biological_processmonoatomic ion homeostasis
C0050829biological_processdefense response to Gram-negative bacterium
C0060170cellular_componentciliary membrane
C0070062cellular_componentextracellular exosome
C0071692biological_processprotein localization to extracellular region
C0072218biological_processmetanephric ascending thin limb development
C0072221biological_processmetanephric distal convoluted tubule development
C0072233biological_processmetanephric thick ascending limb development
C0098552cellular_componentside of membrane
C0140367biological_processantibacterial innate immune response
C1990266biological_processneutrophil migration
Functional Information from PROSITE/UniProt
site_idPS00010
Number of Residues12
DetailsASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFsCvC
ChainResidueDetails
ACYS83-CYS94
ACYS126-CYS137
site_idPS00682
Number of Residues41
DetailsZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C
ChainResidueDetails
AVAL487-CYS527
site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CtCqeGFtgdglt..C
ChainResidueDetails
ACYS50-CYS63
ACYS92-CYS106
ACYS135-CYS150
site_idPS01187
Number of Residues28
DetailsEGF_CA Calcium-binding EGF-like domain signature. DlDECaipgahn.......Csanss..CvNtpgsFsC
ChainResidueDetails
AASP65-CYS92
AASP108-CYS135
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues62
DetailsDomain: {"description":"EGF-like 4","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues190
DetailsRegion: {"description":"ZP-N","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues23
DetailsRegion: {"description":"Flexible ZP-N/ZP-C linker; important for secretion and polymerization into filaments","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues22
DetailsRegion: {"description":"Internal hydrophobic patch (IHP)","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247035

PDB entries from 2026-01-07

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