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6TQK

Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000922cellular_componentspindle pole
A0001822biological_processkidney development
A0002251biological_processorgan or tissue specific immune response
A0003091biological_processrenal water homeostasis
A0003094biological_processglomerular filtration
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005783cellular_componentendoplasmic reticulum
A0005796cellular_componentGolgi lumen
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006629biological_processlipid metabolic process
A0006874biological_processintracellular calcium ion homeostasis
A0006883biological_processintracellular sodium ion homeostasis
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0006968biological_processcellular defense response
A0006986biological_processresponse to unfolded protein
A0007029biological_processendoplasmic reticulum organization
A0007157biological_processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
A0007159biological_processleukocyte cell-cell adhesion
A0008217biological_processregulation of blood pressure
A0008285biological_processnegative regulation of cell population proliferation
A0008380biological_processRNA splicing
A0009410biological_processresponse to xenobiotic stimulus
A0009414biological_processresponse to water deprivation
A0009986cellular_componentcell surface
A0010467biological_processgene expression
A0015747biological_processurate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0019864molecular_functionIgG binding
A0019898cellular_componentextrinsic component of membrane
A0030643biological_processintracellular phosphate ion homeostasis
A0030644biological_processintracellular chloride ion homeostasis
A0032496biological_processresponse to lipopolysaccharide
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0033555biological_processmulticellular organismal response to stress
A0034620biological_processcellular response to unfolded protein
A0034976biological_processresponse to endoplasmic reticulum stress
A0035809biological_processregulation of urine volume
A0036503biological_processERAD pathway
A0044861biological_processprotein transport into plasma membrane raft
A0045087biological_processinnate immune response
A0046720biological_processcitric acid secretion
A0048871biological_processmulticellular organismal-level homeostasis
A0048878biological_processchemical homeostasis
A0050801biological_processmonoatomic ion homeostasis
A0050829biological_processdefense response to Gram-negative bacterium
A0050891biological_processmulticellular organismal-level water homeostasis
A0051223biological_processregulation of protein transport
A0055062biological_processphosphate ion homeostasis
A0055064biological_processchloride ion homeostasis
A0055074biological_processcalcium ion homeostasis
A0055075biological_processpotassium ion homeostasis
A0055078biological_processsodium ion homeostasis
A0060073biological_processmicturition
A0060170cellular_componentciliary membrane
A0061077biological_processchaperone-mediated protein folding
A0070062cellular_componentextracellular exosome
A0070294biological_processrenal sodium ion absorption
A0071918biological_processurea transmembrane transport
A0072044biological_processcollecting duct development
A0072051biological_processjuxtaglomerular apparatus development
A0072070biological_processloop of Henle development
A0072218biological_processmetanephric ascending thin limb development
A0072221biological_processmetanephric distal convoluted tubule development
A0072233biological_processmetanephric thick ascending limb development
A0072665biological_processprotein localization to vacuole
A0097190biological_processapoptotic signaling pathway
A0097709biological_processconnective tissue replacement
A0097744biological_processrenal urate salt excretion
A0098552cellular_componentside of membrane
A0140367biological_processantibacterial innate immune response
A1990266biological_processneutrophil migration
B0000922cellular_componentspindle pole
B0001822biological_processkidney development
B0002251biological_processorgan or tissue specific immune response
B0003091biological_processrenal water homeostasis
B0003094biological_processglomerular filtration
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005783cellular_componentendoplasmic reticulum
B0005796cellular_componentGolgi lumen
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006629biological_processlipid metabolic process
B0006874biological_processintracellular calcium ion homeostasis
B0006883biological_processintracellular sodium ion homeostasis
B0006914biological_processautophagy
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0006968biological_processcellular defense response
B0006986biological_processresponse to unfolded protein
B0007029biological_processendoplasmic reticulum organization
B0007157biological_processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
B0007159biological_processleukocyte cell-cell adhesion
B0008217biological_processregulation of blood pressure
B0008285biological_processnegative regulation of cell population proliferation
B0008380biological_processRNA splicing
B0009410biological_processresponse to xenobiotic stimulus
B0009414biological_processresponse to water deprivation
B0009986cellular_componentcell surface
B0010467biological_processgene expression
B0015747biological_processurate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0019864molecular_functionIgG binding
B0019898cellular_componentextrinsic component of membrane
B0030643biological_processintracellular phosphate ion homeostasis
B0030644biological_processintracellular chloride ion homeostasis
B0032496biological_processresponse to lipopolysaccharide
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0033555biological_processmulticellular organismal response to stress
B0034620biological_processcellular response to unfolded protein
B0034976biological_processresponse to endoplasmic reticulum stress
B0035809biological_processregulation of urine volume
B0036503biological_processERAD pathway
B0044861biological_processprotein transport into plasma membrane raft
B0045087biological_processinnate immune response
B0046720biological_processcitric acid secretion
B0048871biological_processmulticellular organismal-level homeostasis
B0048878biological_processchemical homeostasis
B0050801biological_processmonoatomic ion homeostasis
B0050829biological_processdefense response to Gram-negative bacterium
B0050891biological_processmulticellular organismal-level water homeostasis
B0051223biological_processregulation of protein transport
B0055062biological_processphosphate ion homeostasis
B0055064biological_processchloride ion homeostasis
B0055074biological_processcalcium ion homeostasis
B0055075biological_processpotassium ion homeostasis
B0055078biological_processsodium ion homeostasis
B0060073biological_processmicturition
B0060170cellular_componentciliary membrane
B0061077biological_processchaperone-mediated protein folding
B0070062cellular_componentextracellular exosome
B0070294biological_processrenal sodium ion absorption
B0071918biological_processurea transmembrane transport
B0072044biological_processcollecting duct development
B0072051biological_processjuxtaglomerular apparatus development
B0072070biological_processloop of Henle development
B0072218biological_processmetanephric ascending thin limb development
B0072221biological_processmetanephric distal convoluted tubule development
B0072233biological_processmetanephric thick ascending limb development
B0072665biological_processprotein localization to vacuole
B0097190biological_processapoptotic signaling pathway
B0097709biological_processconnective tissue replacement
B0097744biological_processrenal urate salt excretion
B0098552cellular_componentside of membrane
B0140367biological_processantibacterial innate immune response
B1990266biological_processneutrophil migration
C0000922cellular_componentspindle pole
C0001822biological_processkidney development
C0002251biological_processorgan or tissue specific immune response
C0003091biological_processrenal water homeostasis
C0003094biological_processglomerular filtration
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005783cellular_componentendoplasmic reticulum
C0005796cellular_componentGolgi lumen
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006629biological_processlipid metabolic process
C0006874biological_processintracellular calcium ion homeostasis
C0006883biological_processintracellular sodium ion homeostasis
C0006914biological_processautophagy
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0006968biological_processcellular defense response
C0006986biological_processresponse to unfolded protein
C0007029biological_processendoplasmic reticulum organization
C0007157biological_processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
C0007159biological_processleukocyte cell-cell adhesion
C0008217biological_processregulation of blood pressure
C0008285biological_processnegative regulation of cell population proliferation
C0008380biological_processRNA splicing
C0009410biological_processresponse to xenobiotic stimulus
C0009414biological_processresponse to water deprivation
C0009986cellular_componentcell surface
C0010467biological_processgene expression
C0015747biological_processurate transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016324cellular_componentapical plasma membrane
C0019864molecular_functionIgG binding
C0019898cellular_componentextrinsic component of membrane
C0030643biological_processintracellular phosphate ion homeostasis
C0030644biological_processintracellular chloride ion homeostasis
C0032496biological_processresponse to lipopolysaccharide
C0033209biological_processtumor necrosis factor-mediated signaling pathway
C0033555biological_processmulticellular organismal response to stress
C0034620biological_processcellular response to unfolded protein
C0034976biological_processresponse to endoplasmic reticulum stress
C0035809biological_processregulation of urine volume
C0036503biological_processERAD pathway
C0044861biological_processprotein transport into plasma membrane raft
C0045087biological_processinnate immune response
C0046720biological_processcitric acid secretion
C0048871biological_processmulticellular organismal-level homeostasis
C0048878biological_processchemical homeostasis
C0050801biological_processmonoatomic ion homeostasis
C0050829biological_processdefense response to Gram-negative bacterium
C0050891biological_processmulticellular organismal-level water homeostasis
C0051223biological_processregulation of protein transport
C0055062biological_processphosphate ion homeostasis
C0055064biological_processchloride ion homeostasis
C0055074biological_processcalcium ion homeostasis
C0055075biological_processpotassium ion homeostasis
C0055078biological_processsodium ion homeostasis
C0060073biological_processmicturition
C0060170cellular_componentciliary membrane
C0061077biological_processchaperone-mediated protein folding
C0070062cellular_componentextracellular exosome
C0070294biological_processrenal sodium ion absorption
C0071918biological_processurea transmembrane transport
C0072044biological_processcollecting duct development
C0072051biological_processjuxtaglomerular apparatus development
C0072070biological_processloop of Henle development
C0072218biological_processmetanephric ascending thin limb development
C0072221biological_processmetanephric distal convoluted tubule development
C0072233biological_processmetanephric thick ascending limb development
C0072665biological_processprotein localization to vacuole
C0097190biological_processapoptotic signaling pathway
C0097709biological_processconnective tissue replacement
C0097744biological_processrenal urate salt excretion
C0098552cellular_componentside of membrane
C0140367biological_processantibacterial innate immune response
C1990266biological_processneutrophil migration
Functional Information from PROSITE/UniProt
site_idPS00010
Number of Residues12
DetailsASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFsCvC
ChainResidueDetails
ACYS83-CYS94
ACYS126-CYS137

site_idPS00682
Number of Residues41
DetailsZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C
ChainResidueDetails
AVAL487-CYS527

site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CtCqeGFtgdglt..C
ChainResidueDetails
ACYS50-CYS63
ACYS92-CYS106
ACYS135-CYS150

site_idPS01187
Number of Residues28
DetailsEGF_CA Calcium-binding EGF-like domain signature. DlDECaipgahn.......Csanss..CvNtpgsFsC
ChainResidueDetails
AASP65-CYS92
AASP108-CYS135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsSITE: Cleavage => ECO:0000269|PubMed:18375198
ChainResidueDetails
APHE587
BPHE587
CPHE587

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32616672
ChainResidueDetails
AASN38
BASN38
CASN38

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:7PFP, ECO:0007744|PDB:7Q3N
ChainResidueDetails
AASN76
AASN80
BASN76
BASN80
CASN76
CASN80

site_idSWS_FT_FI4
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:7PFP, ECO:0007744|PDB:7Q3N
ChainResidueDetails
AASN232
BASN232
CASN232

site_idSWS_FT_FI5
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:7PFP, ECO:0007744|PDB:7Q3N
ChainResidueDetails
AASN275
BASN275
CASN275

site_idSWS_FT_FI6
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:33196145, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:6TQK, ECO:0007744|PDB:6TQL, ECO:0007744|PDB:7PFP
ChainResidueDetails
AASN322
BASN322
CASN322

site_idSWS_FT_FI7
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:32815518, ECO:0000269|PubMed:33196145, ECO:0000269|PubMed:35273390, ECO:0007744|PDB:6TQK, ECO:0007744|PDB:6TQL, ECO:0007744|PDB:6ZS5, ECO:0007744|PDB:6ZYA, ECO:0007744|PDB:7PFP
ChainResidueDetails
AASN396
BASN396
CASN396

site_idSWS_FT_FI8
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; alternate => ECO:0000269|PubMed:32616672, ECO:0000269|PubMed:32815518, ECO:0000269|PubMed:33196145, ECO:0007744|PDB:6TQK, ECO:0007744|PDB:6TQL, ECO:0007744|PDB:6ZS5, ECO:0007744|PDB:6ZYA, ECO:0007744|PDB:7PFP
ChainResidueDetails
AASN513
BASN513
CASN513

222926

PDB entries from 2024-07-24

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