6KSS
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4UQK
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![BU of 4uqk by Molmil](/molmil-images/mine/4uqk) | Electron density map of GluA2em in complex with quisqualate and LY451646 | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2 | Authors: | Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. | Deposit date: | 2014-06-24 | Release date: | 2014-08-13 | Last modified: | 2017-08-02 | Method: | ELECTRON MICROSCOPY (16.4 Å) | Cite: | Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
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6ZYU
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![BU of 6zyu by Molmil](/molmil-images/mine/6zyu) | Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549 | Descriptor: | (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide, ACETATE ION, ... | Authors: | Dorosz, J, Christensen, K.M, Kastrup, J.S. | Deposit date: | 2020-08-03 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. Acs Chem Neurosci, 12, 2021
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6U5S
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6CNA
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![BU of 6cna by Molmil](/molmil-images/mine/6cna) | GluN1-GluN2B NMDA receptors with exon 5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | Furukawa, H, Grant, T, Grigorieff, N. | Deposit date: | 2018-03-07 | Release date: | 2018-10-03 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors. Neuron, 98, 2018
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7VM2
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1FTJ
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5VOV
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![BU of 5vov by Molmil](/molmil-images/mine/5vov) | Structure of AMPA receptor-TARP complex | Descriptor: | Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | Authors: | Zhao, Y, Chen, S, Wang, Y.S, Shekhar, M, Tajkhorshid, E, Gouaux, E. | Deposit date: | 2017-05-03 | Release date: | 2017-07-12 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM. Cell, 170, 2017
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5H8N
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![BU of 5h8n by Molmil](/molmil-images/mine/5h8n) | Structure of the human GluN1/GluN2A LBD in complex with NAM | Descriptor: | 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide, CALCIUM ION, GLUTAMIC ACID, ... | Authors: | Wallweber, H.J.A, Lupardus, P.J. | Deposit date: | 2015-12-23 | Release date: | 2016-02-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
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5I59
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![BU of 5i59 by Molmil](/molmil-images/mine/5i59) | Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007 | Descriptor: | 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, GLYCINE, ... | Authors: | Mou, T.-C, Sprang, S.R, Hansen, K.B. | Deposit date: | 2016-02-14 | Release date: | 2016-09-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
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5WEK
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![BU of 5wek by Molmil](/molmil-images/mine/5wek) | GluA2 bound to antagonist ZK and GSG1L in digitonin, state 1 | Descriptor: | Chimera of Glutamate receptor 2,Germ cell-specific gene 1-like protein, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | Authors: | Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I. | Deposit date: | 2017-07-10 | Release date: | 2017-08-02 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Channel opening and gating mechanism in AMPA-subtype glutamate receptors. Nature, 549, 2017
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7QHH
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![BU of 7qhh by Molmil](/molmil-images/mine/7qhh) | Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ... | Authors: | Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H. | Deposit date: | 2021-12-12 | Release date: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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7QHB
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![BU of 7qhb by Molmil](/molmil-images/mine/7qhb) | Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ... | Authors: | Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H. | Deposit date: | 2021-12-11 | Release date: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor. Nat Commun, 13, 2022
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6DM0
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![BU of 6dm0 by Molmil](/molmil-images/mine/6dm0) | Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction | Descriptor: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... | Authors: | Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. | Deposit date: | 2018-06-04 | Release date: | 2018-08-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
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4NF6
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![BU of 4nf6 by Molmil](/molmil-images/mine/4nf6) | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA | Descriptor: | (2S,3R)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... | Authors: | Jespersen, A, Tajima, N, Furukawa, H. | Deposit date: | 2013-10-30 | Release date: | 2014-03-12 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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4NF8
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![BU of 4nf8 by Molmil](/molmil-images/mine/4nf8) | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in PEG2000MME | Descriptor: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | Authors: | Jespersen, A, Tajima, N, Furukawa, H. | Deposit date: | 2013-10-30 | Release date: | 2014-03-12 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (1.856 Å) | Cite: | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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6DM1
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![BU of 6dm1 by Molmil](/molmil-images/mine/6dm1) | Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction | Descriptor: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ... | Authors: | Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. | Deposit date: | 2018-06-04 | Release date: | 2018-08-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
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6DLZ
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![BU of 6dlz by Molmil](/molmil-images/mine/6dlz) | Open state GluA2 in complex with STZ after micelle signal subtraction | Descriptor: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit | Authors: | Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I. | Deposit date: | 2018-06-04 | Release date: | 2018-08-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors. Neuron, 99, 2018
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4NF4
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![BU of 4nf4 by Molmil](/molmil-images/mine/4nf4) | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate | Descriptor: | 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... | Authors: | Annie, J, Tajima, N, Furukawa, H. | Deposit date: | 2013-10-30 | Release date: | 2014-03-12 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
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2OJT
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![BU of 2ojt by Molmil](/molmil-images/mine/2ojt) | Structure and mechanism of kainate receptor modulation by anions | Descriptor: | (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, BROMIDE ION, Glutamate receptor, ... | Authors: | Mayer, M.L. | Deposit date: | 2007-01-14 | Release date: | 2007-04-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure and mechanism of kainate receptor modulation by anions. Neuron, 53, 2007
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2PBW
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![BU of 2pbw by Molmil](/molmil-images/mine/2pbw) | Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution | Descriptor: | (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, Glutamate receptor, ionotropic kainate 1 | Authors: | Hald, H, Naur, P, Gajhede, M, Kastrup, J.S. | Deposit date: | 2007-03-29 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282, 2007
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2P2A
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![BU of 2p2a by Molmil](/molmil-images/mine/2p2a) | X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution | Descriptor: | 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Frydenvang, K, Kastrup, J.S, Gajhede, M. | Deposit date: | 2007-03-07 | Release date: | 2007-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J.Med.Chem., 50, 2007
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1IIT
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![BU of 1iit by Molmil](/molmil-images/mine/1iit) | GLUR0 LIGAND BINDING CORE COMPLEX WITH L-SERINE | Descriptor: | SERINE, Slr1257 protein | Authors: | Mayer, M.L, Olson, R, Gouaux, E. | Deposit date: | 2001-04-24 | Release date: | 2001-09-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state. J.Mol.Biol., 311, 2001
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1IIW
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5O4F
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![BU of 5o4f by Molmil](/molmil-images/mine/5o4f) | Structure of GluK3 ligand-binding domain (S1S2) in complex with the agonist LM-12b at 2.10 A resolution | Descriptor: | (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ACETATE ION, CHLORIDE ION, ... | Authors: | Moellerud, S, Frydenvang, K, Kastrup, J.S. | Deposit date: | 2017-05-29 | Release date: | 2017-07-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017
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