6ZYU

Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549

Summary for 6ZYU

Entry DOI	10.2210/pdb6zyu/pdb
Descriptor	Glutamate receptor 2,Glutamate receptor 2, ZINC ION, CACODYLATE ION, ... (10 entities in total)
Functional Keywords	glua2-lbd, glua2-s1s2j, ampa receptor, ligand-binding domain, positive allosteric modulator, membrane protein, l483y, n754s, signaling protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	3
Total formula weight	91473.65
Authors	Dorosz, J.,Christensen, K.M.,Kastrup, J.S. (deposition date: 2020-08-03, release date: 2021-08-11, Last modification date: 2024-01-31)
Primary citation	Etse, K.S.,Dorosz, J.,McLain Christensen, K.,Thomas, J.Y.,Botez Pop, I.,Goffin, E.,Colson, T.,Lestage, P.,Danober, L.,Pirotte, B.,Kastrup, J.S.,Francotte, P. Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. Acs Chem Neurosci, 12:2679-2692, 2021 Cited by PubMed: 34242002 DOI: 10.1021/acschemneuro.1c00255 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation