6ZYU
Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549
Summary for 6ZYU
Entry DOI | 10.2210/pdb6zyu/pdb |
Descriptor | Glutamate receptor 2,Glutamate receptor 2, ZINC ION, CACODYLATE ION, ... (10 entities in total) |
Functional Keywords | glua2-lbd, glua2-s1s2j, ampa receptor, ligand-binding domain, positive allosteric modulator, membrane protein, l483y, n754s, signaling protein |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 3 |
Total formula weight | 91473.65 |
Authors | Dorosz, J.,Christensen, K.M.,Kastrup, J.S. (deposition date: 2020-08-03, release date: 2021-08-11, Last modification date: 2024-01-31) |
Primary citation | Etse, K.S.,Dorosz, J.,McLain Christensen, K.,Thomas, J.Y.,Botez Pop, I.,Goffin, E.,Colson, T.,Lestage, P.,Danober, L.,Pirotte, B.,Kastrup, J.S.,Francotte, P. Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. Acs Chem Neurosci, 12:2679-2692, 2021 Cited by PubMed: 34242002DOI: 10.1021/acschemneuro.1c00255 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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