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6EHV
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BU of 6ehv by Molmil
scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Authors:Hargreaves, D.
Deposit date:2017-09-15
Release date:2017-11-08
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
To Be Published
7TI6
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BU of 7ti6 by Molmil
Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PCT64_LMCA Fab heavy chain, PCT64_LMCA light chain (wild type)
Authors:Omorodion, O, Wilson, I.A.
Deposit date:2022-01-12
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.
Immunity, 55, 2022
6EHW
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BU of 6ehw by Molmil
scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Authors:Hargreaves, D.
Deposit date:2017-09-15
Release date:2017-11-08
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
To Be Published
7X94
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BU of 7x94 by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab712
Descriptor: Ab712 heavy chain, Ab712 light chain, Spike glycoprotein, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2023-03-22
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents.
Iscience, 26, 2023
7X96
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BU of 7x96 by Molmil
The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab847
Descriptor: Ab847 heavy chain, Ab847 light chain, Spike glycoprotein, ...
Authors:Kamada, K, Shirouzu, M.
Deposit date:2022-03-15
Release date:2023-03-22
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents.
Iscience, 26, 2023
4LHJ
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BU of 4lhj by Molmil
Ricin A chain bound to camelid nanobody (VHH5)
Descriptor: CHLORIDE ION, Camelid antibody, Ricin
Authors:Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N.
Deposit date:2013-07-01
Release date:2014-06-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
4ZS7
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BU of 4zs7 by Molmil
Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
Descriptor: Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain
Authors:Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
6EHX
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BU of 6ehx by Molmil
scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Descriptor: scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
Authors:Hargreaves, D.
Deposit date:2017-09-15
Release date:2017-11-08
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:scFv AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in drug discovery
To Be Published
6APB
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BU of 6apb by Molmil
Crystal Structure of Non-Neutralizing Infant Antibody ADI-14359 in Complex with Postfusion RSV F Glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-14359 Fab Light Chain, Fusion glycoprotein F0,Fusion glycoprotein F0, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2017-08-17
Release date:2018-03-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.
Immunity, 48, 2018
6P8N
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BU of 6p8n by Molmil
Crystal Structure of Antibody P-p1f1 in Complex with eOD-GT8
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ...
Authors:Weidle, C, Pancera, M.
Deposit date:2019-06-07
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.
Cell Rep, 29, 2019
7N5H
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BU of 7n5h by Molmil
Cryo-EM structure of broadly neutralizing antibody 2-36 in complex with prefusion SARS-CoV-2 spike glycoprotein
Descriptor: 2-36 Fab heavy chain, 2-36 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Casner, R.G, Cerutti, G, Shapiro, L.
Deposit date:2021-06-05
Release date:2021-11-03
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses.
Emerg Microbes Infect, 11, 2022
8EK1
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BU of 8ek1 by Molmil
Cryo-EM structure of a potent anti-malarial antibody L9 in complex with Plasmodium falciparum circumsporozoite protein (PfCSP)(dominant class)
Descriptor: Circumsporozoite protein, L9 Fab heavy chain, L9 Fab light chain
Authors:Tripathi, P, Kwong, P.D.
Deposit date:2022-09-19
Release date:2023-03-15
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope.
Structure, 31, 2023
6U6O
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BU of 6u6o by Molmil
Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846
Descriptor: DH846 Fab heavy chain, DH846 Fab light chain
Authors:Chen, W.-H, Choe, M, Saunders, K.O, Joyce, M.G.
Deposit date:2019-08-30
Release date:2021-03-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.806 Å)
Cite:Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.
Plos Pathog., 17, 2021
6U6M
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BU of 6u6m by Molmil
Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH840.1
Descriptor: DH840.1 Fab heavy chain, DH840.1 Fab light chain
Authors:Chen, W.-H, Choe, M, Saunders, K.O, Joyce, M.G.
Deposit date:2019-08-30
Release date:2021-03-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.683 Å)
Cite:Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.
Plos Pathog., 17, 2021
7S5P
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BU of 7s5p by Molmil
Crystal structure of SARS-CoV-2 B.1.351 variant receptor binding domain in complex with neutralizing antibody CS23
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CS23 Heavy chain, ...
Authors:Yuan, M, Wilson, I.A.
Deposit date:2021-09-11
Release date:2022-03-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.
Science, 375, 2022
7RYV
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BU of 7ryv by Molmil
Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques
Descriptor: Ab1573 Fab heavy chain, Ab1573 Fab light chain
Authors:Yang, Z, Bjorkman, P.J.
Deposit date:2021-08-26
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.
Nat Commun, 13, 2022
7RYU
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BU of 7ryu by Molmil
Anti-HIV neutralizing antibody Ab1303 Fab isolated from sequentially immunized mcaques
Descriptor: Ab1303 Fab heavy chain, Ab1303 Fab light chain
Authors:Yang, Z, Bjorkman, P.J.
Deposit date:2021-08-26
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.
Nat Commun, 13, 2022
6APC
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BU of 6apc by Molmil
Crystal Structure of Infant Antibody ADI-19425
Descriptor: Epididymis luminal protein 214, IGL@ protein, SULFATE ION
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2017-08-17
Release date:2018-03-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.
Immunity, 48, 2018
6APD
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BU of 6apd by Molmil
Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425
Descriptor: AM22 Fab Heavy Chain,IGH@ protein, AM22 Fab Light Chain,Uncharacterized protein, Fusion glycoprotein F0,Envelope glycoprotein, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2017-08-17
Release date:2018-03-21
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.
Immunity, 48, 2018
8F2J
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BU of 8f2j by Molmil
Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ...
Authors:Sankhala, R.S, Joyce, M.G.
Deposit date:2022-11-08
Release date:2023-12-13
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Antibody Targeting of Conserved Sites of Vulnerability on the SARS-CoV-2 Spike Receptor-Binding Domain.
To Be Published
8F2X
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BU of 8f2x by Molmil
Crystal structure of antibody WRAIR-2123 in complex with SARS-CoV-2 receptor binding domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, WRAIR-2123 Fab Heavy chain, ...
Authors:Sankhala, R.S, Joyce, G.M.
Deposit date:2022-11-08
Release date:2024-04-17
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Antibody Targeting of Conserved Sites of Vulnerability on the SARS-CoV-2 Spike Receptor-Binding Domain
To Be Published
7MF1
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BU of 7mf1 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 47D1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 47D1 Fab heavy chain, ...
Authors:Yuan, M, Zhu, X, Wilson, I.A.
Deposit date:2021-04-08
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2.
Cell Rep, 35, 2021
7NX6
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BU of 7nx6 by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-222 Fab Heavy chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NXA
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BU of 7nxa by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 B.1.351 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-222 Fab heavy chain, COVOX-222 Fab light chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NX7
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BU of 7nx7 by Molmil
Crystal structure of the K417N mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CITRIC ACID, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021

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数据于2024-07-24公开中

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