6APB

Crystal Structure of Non-Neutralizing Infant Antibody ADI-14359 in Complex with Postfusion RSV F Glycoprotein

Summary for 6APB

• Entry DOI: 10.2210/pdb6apb/pdb
• Descriptor: Fusion glycoprotein F0,Fusion glycoprotein F0, IgG H chain, ADI-14359 Fab Light Chain, ... (4 entities in total)
• Functional Keywords: viral fusion glycoprotein, immunoglobulin, respiratory syncytial virus, immune system
• Biological source: Human respiratory syncytial virus; More
• Total number of polymer chains: 5
• Total formula weight: 219044.04

Authors

Gilman, M.S.A.,McLellan, J.S. (deposition date: 2017-08-17, release date: 2018-03-21, Last modification date: 2023-10-04)

• Primary citation: Goodwin, E.,Gilman, M.S.A.,Wrapp, D.,Chen, M.,Ngwuta, J.O.,Moin, S.M.,Bai, P.,Sivasubramanian, A.,Connor, R.I.,Wright, P.F.,Graham, B.S.,McLellan, J.S.,Walker, L.M.; Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.; Immunity, 48:339-349.e5, 2018; PubMed: 29396163; DOI: 10.1016/j.immuni.2018.01.005

Experimental method

X-RAY DIFFRACTION (3 Å)