5Z6K
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5Z6J
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5Z6F
| High-pressure Crystal Structure Analysis of DHFR(0.1 MPa) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Watanabe, N, Nagae, T, Yamada, H. | Deposit date: | 2018-01-22 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP. Acta Crystallogr D Struct Biol, 74, 2018
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5W3Q
| L28F E.coli DHFR in complex with NADPH | Descriptor: | CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Oyen, D, Wright, P.E, Wilson, I.A. | Deposit date: | 2017-06-08 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
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5UJX
| Crystal structure of DHFR in 20% Isopropanol | Descriptor: | CALCIUM ION, CHLORIDE ION, Dihydrofolate reductase, ... | Authors: | Cuneo, M.J, Agarwal, P.K. | Deposit date: | 2017-01-19 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Modulating Enzyme Activity by Altering Protein Dynamics with Solvent. Biochemistry, 57, 2018
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5UJF
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5UIP
| structure of DHFR with bound DAP, p-ABG and NADP | Descriptor: | Dihydrofolate reductase, N-(4-aminobenzene-1-carbonyl)-L-glutamic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Pedersen, L.C, London, R.E. | Deposit date: | 2017-01-14 | Release date: | 2017-11-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
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5UIO
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5UII
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5UIH
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5U27
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5U26
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5T7O
| Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... | Authors: | Di Pisa, F, Dello Iacono, L, Bonucci, A, Mangani, S. | Deposit date: | 2016-09-05 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE To Be Published
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5T0L
| Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15) | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-[4-(3,4-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4-diamine, ... | Authors: | Thomas, S.B, Chen, Z, Lu, H, Li, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-09-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. ACS Med Chem Lett, 7, 2016
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5SSW
| DHFR:NADP+:FOL complex at 270 K (multi-crystal) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-07-03 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | DHFR:NADP+:FOL complex at 270 K To Be Published
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5SSV
| DHFR:NADP+:FOL complex at 270 K (crystal 4) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-07-03 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | DHFR:NADP+:FOL complex at 270 K To Be Published
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5SSU
| DHFR:NADP+:FOL complex at 270 K (crystal 3) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-07-03 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | DHFR:NADP+:FOL complex at 270 K To Be Published
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5SST
| DHFR:NADP+:FOL complex at 270 K (crystal 2) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-07-03 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | DHFR:NADP+:FOL complex at 270 K To Be Published
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5SSS
| DHFR:NADP+:FOL complex at 270 K (crystal 1) | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | Deposit date: | 2022-07-03 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | DHFR:NADP+:FOL complex at 270 K To Be Published
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5SDB
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5SDA
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5SD9
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5SD8
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5SD7
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5SD6
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